BDBM50318181 CHEMBL1095776::N4-(2-Isopropylphenyl)-6-(2,4-dichlorobenzyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
SMILES: CC(C)c1ccccc1Nc1nc(N)nc2[nH]c(Cc3ccc(Cl)cc3Cl)cc12
InChI Key: InChIKey=GEWZCPIATCKFBZ-UHFFFAOYSA-N
Data: 4 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human)) | BDBM50318181 (CHEMBL1095776 | N4-(2-Isopropylphenyl)-6-(2,4-dich...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >3.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University Curated by ChEMBL | Assay Description Inhibition of VEGFR2 phosphorylation in human U251 cells after 10 mins by FLISA | Bioorg Med Chem 18: 3575-87 (2010) Article DOI: 10.1016/j.bmc.2010.03.052 BindingDB Entry DOI: 10.7270/Q2V69JRB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Platelet-derived growth factor receptor beta (Homo sapiens (Human)) | BDBM50318181 (CHEMBL1095776 | N4-(2-Isopropylphenyl)-6-(2,4-dich...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University Curated by ChEMBL | Assay Description Inhibition of PDGFRbeta phosphorylation in human SF539 cells after 10 mins by FLISA | Bioorg Med Chem 18: 3575-87 (2010) Article DOI: 10.1016/j.bmc.2010.03.052 BindingDB Entry DOI: 10.7270/Q2V69JRB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vascular endothelial growth factor receptor 1 (Homo sapiens (Human)) | BDBM50318181 (CHEMBL1095776 | N4-(2-Isopropylphenyl)-6-(2,4-dich...) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.63E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University Curated by ChEMBL | Assay Description Inhibition of VEGFR1 phosphorylation in human A498 cells after 10 mins by FLISA | Bioorg Med Chem 18: 3575-87 (2010) Article DOI: 10.1016/j.bmc.2010.03.052 BindingDB Entry DOI: 10.7270/Q2V69JRB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM50318181 (CHEMBL1095776 | N4-(2-Isopropylphenyl)-6-(2,4-dich...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 9.64E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University Curated by ChEMBL | Assay Description Inhibition of EGFR phosphorylation in human A431 cells after 10 mins by FLISA | Bioorg Med Chem 18: 3575-87 (2010) Article DOI: 10.1016/j.bmc.2010.03.052 BindingDB Entry DOI: 10.7270/Q2V69JRB | |||||||||||
More data for this Ligand-Target Pair |