BDBM50318626 CHEMBL1082763::N-Methyl-(3-phenylsulfonyl)-6,7,8,9-tetrahydropyrazolo[1,5-a]quinazolin-2-amine

SMILES: CNc1nn2c3CCCCc3cnc2c1S(=O)(=O)c1ccccc1

InChI Key: InChIKey=YTZANMHQMXVVRA-UHFFFAOYSA-N

Data: 3 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50318626   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50318626 (CHEMBL1082763 | N-Methyl-(3-phenylsulfonyl)-6,7,8,...) Show SMILES CNc1nn2c3CCCCc3cnc2c1S(=O)(=O)c1ccccc1 Show InChI InChI=1S/C17H18N4O2S/c1-18-16-15(24(22,23)13-8-3-2-4-9-13)17-19-11-12-7-5-6-10-14(12)21(17)20-16/h2-4,8-9,11H,5-7,10H2,1H3,(H,18,20)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	0.112	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Displacement of [3H]lysergic acid diethylamide from human recombinant 5HT6 receptor expressed in human HeLa cells				J Med Chem 53: 5186-96 (2010) Article DOI: 10.1021/jm100350r BindingDB Entry DOI: 10.7270/Q26T0NMP
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50318626 (CHEMBL1082763 | N-Methyl-(3-phenylsulfonyl)-6,7,8,...) Show SMILES CNc1nn2c3CCCCc3cnc2c1S(=O)(=O)c1ccccc1 Show InChI InChI=1S/C17H18N4O2S/c1-18-16-15(24(22,23)13-8-3-2-4-9-13)17-19-11-12-7-5-6-10-14(12)21(17)20-16/h2-4,8-9,11H,5-7,10H2,1H3,(H,18,20)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	0.259	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP release				J Med Chem 53: 5186-96 (2010) Article DOI: 10.1021/jm100350r BindingDB Entry DOI: 10.7270/Q26T0NMP
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2B (Homo sapiens (Human))	BDBM50318626 (CHEMBL1082763 | N-Methyl-(3-phenylsulfonyl)-6,7,8,...) Show SMILES CNc1nn2c3CCCCc3cnc2c1S(=O)(=O)c1ccccc1 Show InChI InChI=1S/C17H18N4O2S/c1-18-16-15(24(22,23)13-8-3-2-4-9-13)17-19-11-12-7-5-6-10-14(12)21(17)20-16/h2-4,8-9,11H,5-7,10H2,1H3,(H,18,20)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	153	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as inhibition of alpha-Me-serotonin-induced intracellular calcium mobi...				J Med Chem 53: 5186-96 (2010) Article DOI: 10.1021/jm100350r BindingDB Entry DOI: 10.7270/Q26T0NMP
					More data for this Ligand-Target Pair