BDBM50319198 4-(N-Isopropyl-ureido)-8-methoxy-3-methyl-1-propyl-imidazo[1,5-a]pyrido[3,2-e]pyrazine::CHEMBL1085373

SMILES: CCCc1nc(C)c2c(NC(=O)NC(C)C)nc3ccc(OC)nc3n12

InChI Key: InChIKey=RZPUOVCDHIQAQM-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50319198   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50319198 (4-(N-Isopropyl-ureido)-8-methoxy-3-methyl-1-propyl...) Show SMILES CCCc1nc(C)c2c(NC(=O)NC(C)C)nc3ccc(OC)nc3n12 Show InChI InChI=1S/C18H24N6O2/c1-6-7-13-20-11(4)15-16(23-18(25)19-10(2)3)21-12-8-9-14(26-5)22-17(12)24(13)15/h8-10H,6-7H2,1-5H3,(H2,19,21,23,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	381	n/a	n/a	n/a	n/a	n/a	n/a
Biotie Therapies GmbH Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio...				J Med Chem 53: 4399-411 (2010) Article DOI: 10.1021/jm1002793 BindingDB Entry DOI: 10.7270/Q2MK6D3N
					More data for this Ligand-Target Pair