BDBM50319718 2-amino-N-(7-chloro-1-oxo-1,2-dihydroisoquinolin-6-yl)acetamide::CHEMBL1083114

SMILES: NCC(=O)Nc1cc2cc[nH]c(=O)c2cc1Cl

InChI Key: InChIKey=VWNTXLKHVHGBHD-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50319718   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50319718 (2-amino-N-(7-chloro-1-oxo-1,2-dihydroisoquinolin-6...) Show SMILES NCC(=O)Nc1cc2cc[nH]c(=O)c2cc1Cl Show InChI InChI=1S/C11H10ClN3O2/c12-8-4-7-6(1-2-14-11(7)17)3-9(8)15-10(16)5-13/h1-4H,5,13H2,(H,14,17)(H,15,16)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer-Ingelheim Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of ROCK2 by luciferase based ATP detection assay				Bioorg Med Chem Lett 20: 3746-9 (2010) Article DOI: 10.1016/j.bmcl.2010.04.069 BindingDB Entry DOI: 10.7270/Q2XD12MD
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50319718 (2-amino-N-(7-chloro-1-oxo-1,2-dihydroisoquinolin-6...) Show SMILES NCC(=O)Nc1cc2cc[nH]c(=O)c2cc1Cl Show InChI InChI=1S/C11H10ClN3O2/c12-8-4-7-6(1-2-14-11(7)17)3-9(8)15-10(16)5-13/h1-4H,5,13H2,(H,14,17)(H,15,16)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of ROCK2				Bioorg Med Chem Lett 20: 5153-6 (2010) Article DOI: 10.1016/j.bmcl.2010.07.014 BindingDB Entry DOI: 10.7270/Q2RR1ZDC
					More data for this Ligand-Target Pair