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SMILES: CC(C)(Cc1ccc2ccccc2c1)NC[C@@H](O)COC(C1CC1)c1ccccc1

InChI Key: InChIKey=GNOTVFACNIFDMT-DCWQJPKNSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50320011   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Extracellular calcium-sensing receptor


(Homo sapiens (Human))		BDBM50320011
PNG
((2R)-1-(cyclopropyl(phenyl)methoxy)-3-(2-methyl-1-...)
Show SMILES CC(C)(Cc1ccc2ccccc2c1)NC[C@@H](O)COC(C1CC1)c1ccccc1 |r|
Show InChI InChI=1S/C27H33NO2/c1-27(2,17-20-12-13-21-8-6-7-11-24(21)16-20)28-18-25(29)19-30-26(23-14-15-23)22-9-4-3-5-10-22/h3-13,16,23,25-26,28-29H,14-15,17-19H2,1-2H3/t25-,26?/m1/s1
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n/an/a 70n/an/an/an/an/an/a



Central Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human CaSR expressed in rat PC12 cells transfected with zif promoter/luciferase by reporter gene assay

Bioorg Med Chem Lett 20: 3809-13 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.035
BindingDB Entry DOI: 10.7270/Q2765FGD
More data for this
Ligand-Target Pair