BDBM50320795 CHEMBL1164235::N-(3-cyano-4-(3-(hydroxymethyl)phenyl)-6-(2-hydroxyphenyl)pyridin-2-yl)thiophene-2-carboxamide
SMILES: OCc1cccc(c1)-c1cc(nc(NC(=O)c2cccs2)c1C#N)-c1ccccc1O
InChI Key: InChIKey=XMZCGKIJGJHOFR-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G-protein Coupled Receptor 54 (Homo sapiens (Human)) | BDBM50320795 (CHEMBL1164235 | N-(3-cyano-4-(3-(hydroxymethyl)phe...) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company, Ltd Curated by ChEMBL | Assay Description Displacement of [125I]metastin(40-54) from human GPR54 receptor expressed in CHO cells after 60 mins by scintillation counting | Bioorg Med Chem 18: 3841-59 (2010) Article DOI: 10.1016/j.bmc.2010.04.036 BindingDB Entry DOI: 10.7270/Q22807S6 | |||||||||||
More data for this Ligand-Target Pair |