BDBM50321043 1-(5-Chloro-2-trifluoromethyl-benzyl)-7-[6-(4-methylpiperazin-1-yl)-pyridin-3-yl]-1,2,3,4-tetrahydro-pyrido[2,3-b]pyrazine::CHEMBL1164180

SMILES: CN1CCN(CC1)c1ccc(cn1)-c1cnc2NCCN(Cc3cc(Cl)ccc3C(F)(F)F)c2c1

InChI Key: InChIKey=LJKJYKWDLJUZHA-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50321043   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
ALK tyrosine kinase receptor (Homo sapiens (Human))	BDBM50321043 (1-(5-Chloro-2-trifluoromethyl-benzyl)-7-[6-(4-meth...) Show SMILES CN1CCN(CC1)c1ccc(cn1)-c1cnc2NCCN(Cc3cc(Cl)ccc3C(F)(F)F)c2c1 Show InChI InChI=1S/C25H26ClF3N6/c1-33-8-10-34(11-9-33)23-5-2-17(14-31-23)18-13-22-24(32-15-18)30-6-7-35(22)16-19-12-20(26)3-4-21(19)25(27,28)29/h2-5,12-15H,6-11,16H2,1H3,(H,30,32)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of ALK by time-resolved fluorescence assay				Bioorg Med Chem 18: 4351-62 (2010) Article DOI: 10.1016/j.bmc.2010.04.087 BindingDB Entry DOI: 10.7270/Q2057GXW
					More data for this Ligand-Target Pair