BDBM50321374 4-cyano-N-(4-(1,3-dimethyl-2-(methylsulfonylimino)hexahydropyrimidin-5-yl)-2-(4,4-dimethylcyclohex-1-enyl)phenyl)-1H-imidazole-2-carboxamide::CHEMBL1169980

SMILES: CN1CC(CN(C)C1=NS(C)(=O)=O)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCC(C)(C)CC1

InChI Key: InChIKey=WNXZWPZAKWARGG-GDWJVWIDSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50321374   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Macrophage colony stimulating factor receptor (Homo sapiens (Human))	BDBM50321374 (4-cyano-N-(4-(1,3-dimethyl-2-(methylsulfonylimino)...) Show SMILES CN1CC(CN(C)C1=NS(C)(=O)=O)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |t:32,(-4.16,-42.5,;-4.16,-40.96,;-2.81,-40.2,;-2.82,-38.66,;-4.15,-37.88,;-5.48,-38.65,;-6.81,-37.87,;-5.49,-40.19,;-6.82,-40.95,;-8.15,-40.17,;-8.15,-38.63,;-9.65,-39.76,;-8.93,-41.5,;-1.49,-37.89,;-.16,-38.66,;1.18,-37.89,;1.18,-36.34,;2.51,-35.57,;3.84,-36.33,;3.85,-37.87,;5.17,-35.56,;6.58,-36.19,;7.61,-35.04,;6.83,-33.71,;5.32,-34.04,;7.44,-32.3,;8.06,-30.89,;-.16,-35.58,;-1.49,-36.35,;-.16,-34.05,;1.17,-33.28,;1.17,-31.74,;-.16,-30.97,;-.94,-29.63,;.6,-29.63,;-1.49,-31.74,;-1.49,-33.29,)| Show InChI InChI=1S/C26H33N7O3S/c1-26(2)10-8-17(9-11-26)21-12-18(19-15-32(3)25(33(4)16-19)31-37(5,35)36)6-7-22(21)30-24(34)23-28-14-20(13-27)29-23/h6-8,12,14,19H,9-11,15-16H2,1-5H3,(H,28,29)(H,30,34)/b31-25-	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL					Assay Description Inhibition of human FMS by fluorescence polarization				Bioorg Med Chem Lett 20: 3925-9 (2010) Article DOI: 10.1016/j.bmcl.2010.05.013 BindingDB Entry DOI: 10.7270/Q22Z16HG
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