BDBM50321885 (E)-5-((1H-Indol-3yl)methylene)-2-imino-1,3-dimethylimidazolidin-4-one::CHEMBL404232::aplysinopsin
SMILES: CN1C(=N)N(C)\C(=C\c2c[nH]c3ccccc23)C1=O
InChI Key: InChIKey=AZGOVLGMSGAOMP-FZYUQVBKSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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5-hydroxytryptamine receptor 2A (Homo sapiens (Human)) | BDBM50321885 ((E)-5-((1H-Indol-3yl)methylene)-2-imino-1,3-dimeth...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 598 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of North Texas Health Science Center Curated by ChEMBL | Assay Description Displacement of [3H]methylspiperone from human cloned 5HT2A receptor expressed in HEK293 cells after 90 mins by liquid scintillation counting | Bioorg Med Chem 18: 4783-92 (2011) Article DOI: 10.1016/j.bmc.2010.05.017 BindingDB Entry DOI: 10.7270/Q2V69KJ2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 3A (Homo sapiens (Human)) | BDBM50321885 ((E)-5-((1H-Indol-3yl)methylene)-2-imino-1,3-dimeth...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 3.03E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Mississippi Curated by ChEMBL | Assay Description Displacement of [3H]GR65630 from human recombinant 5HT3 receptor expressed in HEKT cells | Bioorg Med Chem 21: 7083-90 (2013) Article DOI: 10.1016/j.bmc.2013.09.011 BindingDB Entry DOI: 10.7270/Q2RJ4KXM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2C (Homo sapiens (Human)) | BDBM50321885 ((E)-5-((1H-Indol-3yl)methylene)-2-imino-1,3-dimeth...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.45E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of North Texas Health Science Center Curated by ChEMBL | Assay Description Displacement of [3H]mesulergine from human cloned 5HT2C receptor expressed in HEK293 cells after 90 mins by liquid scintillation counting | Bioorg Med Chem 18: 4783-92 (2011) Article DOI: 10.1016/j.bmc.2010.05.017 BindingDB Entry DOI: 10.7270/Q2V69KJ2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Amine oxidase [flavin-containing] B (Homo sapiens (Human)) | BDBM50321885 ((E)-5-((1H-Indol-3yl)methylene)-2-imino-1,3-dimeth...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Mississippi Curated by ChEMBL | Assay Description Inhibition of human recombinant MAO-B using kynuramine as substrate preincubated with compound for 15 mins measured after 20 mins by fluorometric ana... | Bioorg Med Chem Lett 22: 4926-9 (2012) Article DOI: 10.1016/j.bmcl.2012.06.058 BindingDB Entry DOI: 10.7270/Q21Z45GF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Amine oxidase (flavin-containing) A (Homo sapiens (Human)) | BDBM50321885 ((E)-5-((1H-Indol-3yl)methylene)-2-imino-1,3-dimeth...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Mississippi Curated by ChEMBL | Assay Description Inhibition of human recombinant MAO-A using kynuramine as substrate preincubated with compound for 15 mins measured after 20 mins by fluorometric ana... | Bioorg Med Chem Lett 22: 4926-9 (2012) Article DOI: 10.1016/j.bmcl.2012.06.058 BindingDB Entry DOI: 10.7270/Q21Z45GF | |||||||||||
More data for this Ligand-Target Pair |