BDBM50322180 3-(2,5-dimethylphenylsulfonyl)-N-isopropylthieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidin-5-amine::CHEMBL1172794::UT-A1 inhibitor D1

SMILES: CC(C)Nc1nc2c(nnn2c2ccsc12)S(=O)(=O)c1cc(C)ccc1C

InChI Key: InChIKey=TZKAXVMSVDWDPN-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50322180   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Urea transporter A1 (UT-A1) (Rattus norvegicus (Rat))	BDBM50322180 (3-(2,5-dimethylphenylsulfonyl)-N-isopropylthieno[2...) Show SMILES CC(C)Nc1nc2c(nnn2c2ccsc12)S(=O)(=O)c1cc(C)ccc1C Show InChI InChI=1S/C18H19N5O2S2/c1-10(2)19-16-15-13(7-8-26-15)23-17(20-16)18(21-22-23)27(24,25)14-9-11(3)5-6-12(14)4/h5-10H,1-4H3,(H,19,20)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of California, San Francisco, San Francisco, CA 94143-0521, USA					Assay Description The urea concentration dependence of UT-A1 inhibition was studied from inhibitor concentration response data (0.3 - 60 µM) using different of ur...				Chem Biol 20: 1235-44 (2013) Article DOI: 10.1016/j.chembiol.2013.08.005 BindingDB Entry DOI: 10.7270/Q22F7M35
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50322180 (3-(2,5-dimethylphenylsulfonyl)-N-isopropylthieno[2...) Show SMILES CC(C)Nc1nc2c(nnn2c2ccsc12)S(=O)(=O)c1cc(C)ccc1C Show InChI InChI=1S/C18H19N5O2S2/c1-10(2)19-16-15-13(7-8-26-15)23-17(20-16)18(21-22-23)27(24,25)14-9-11(3)5-6-12(14)4/h5-10H,1-4H3,(H,19,20)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	350	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP production				Bioorg Med Chem 18: 5282-90 (2010) Article DOI: 10.1016/j.bmc.2010.05.051 BindingDB Entry DOI: 10.7270/Q2F190QT
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50322180 (3-(2,5-dimethylphenylsulfonyl)-N-isopropylthieno[2...) Show SMILES CC(C)Nc1nc2c(nnn2c2ccsc12)S(=O)(=O)c1cc(C)ccc1C Show InChI InChI=1S/C18H19N5O2S2/c1-10(2)19-16-15-13(7-8-26-15)23-17(20-16)18(21-22-23)27(24,25)14-9-11(3)5-6-12(14)4/h5-10H,1-4H3,(H,19,20)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	28.3	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Binding affinity to human recombinant 5HT6 receptor expressed in HEK293 cells by radioligand displacement assay				Bioorg Med Chem 18: 5282-90 (2010) Article DOI: 10.1016/j.bmc.2010.05.051 BindingDB Entry DOI: 10.7270/Q2F190QT
					More data for this Ligand-Target Pair
Urea transporter B (UT-B) (Rattus norvegicus (Rat))	BDBM50322180 (3-(2,5-dimethylphenylsulfonyl)-N-isopropylthieno[2...) Show SMILES CC(C)Nc1nc2c(nnn2c2ccsc12)S(=O)(=O)c1cc(C)ccc1C Show InChI InChI=1S/C18H19N5O2S2/c1-10(2)19-16-15-13(7-8-26-15)23-17(20-16)18(21-22-23)27(24,25)14-9-11(3)5-6-12(14)4/h5-10H,1-4H3,(H,19,20)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of California, San Francisco, San Francisco, CA 94143-0521, USA					Assay Description Erythrocyte suspension (100 µL) was added to each well of a 96-well microplate to which test compounds were added. After 15 min incubation, 20 &...				Chem Biol 20: 1235-44 (2013) Article DOI: 10.1016/j.chembiol.2013.08.005 BindingDB Entry DOI: 10.7270/Q22F7M35
					More data for this Ligand-Target Pair