BDBM50323159 CHEMBL1209321::N-(2-(4-((3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl)piperazin-1-yl)-4-methylpentyl)-N-isopropyl acetamide::N-(2-(4-((3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl)piperazin-1-yl)-4-methylpentyl)-N-isopropylacetamide

SMILES: CC(C)CC(CN(C(C)C)C(C)=O)N1CCN(CC1)C(=O)[C@@H]1CN(C[C@H]1c1ccc(F)cc1F)C(C)(C)C

InChI Key: InChIKey=NRXOSRAXRKFLQU-CUBVPSHMSA-N

Data: 5 IC50  4 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50323159   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50323159 (CHEMBL1209321 | N-(2-(4-((3S,4R)-1-tert-butyl-4-(2...) Show SMILES CC(C)CC(CN(C(C)C)C(C)=O)N1CCN(CC1)C(=O)[C@@H]1CN(C[C@H]1c1ccc(F)cc1F)C(C)(C)C |r| Show InChI InChI=1S/C30H48F2N4O2/c1-20(2)15-24(17-36(21(3)4)22(5)37)33-11-13-34(14-12-33)29(38)27-19-35(30(6,7)8)18-26(27)25-10-9-23(31)16-28(25)32/h9-10,16,20-21,24,26-27H,11-15,17-19H2,1-8H3/t24?,26-,27+/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	49	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Displacement of [125I]NDP-alpha-MSH from human MC4 receptor expressed in CHO cells				Bioorg Med Chem Lett 20: 4483-6 (2010) Article DOI: 10.1016/j.bmcl.2010.06.038 BindingDB Entry DOI: 10.7270/Q2C829GJ
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50323159 (CHEMBL1209321 | N-(2-(4-((3S,4R)-1-tert-butyl-4-(2...) Show SMILES CC(C)CC(CN(C(C)C)C(C)=O)N1CCN(CC1)C(=O)[C@@H]1CN(C[C@H]1c1ccc(F)cc1F)C(C)(C)C |r| Show InChI InChI=1S/C30H48F2N4O2/c1-20(2)15-24(17-36(21(3)4)22(5)37)33-11-13-34(14-12-33)29(38)27-19-35(30(6,7)8)18-26(27)25-10-9-23(31)16-28(25)32/h9-10,16,20-21,24,26-27H,11-15,17-19H2,1-8H3/t24?,26-,27+/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	29	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Agonist activity at human MC4 receptor expressed in CHO cells assessed as increase of alpha-MSH-induced cAMP accumulation				Bioorg Med Chem Lett 20: 4483-6 (2010) Article DOI: 10.1016/j.bmcl.2010.06.038 BindingDB Entry DOI: 10.7270/Q2C829GJ
					More data for this Ligand-Target Pair
Melanocortin receptor 3 (Homo sapiens (Human))	BDBM50323159 (CHEMBL1209321 | N-(2-(4-((3S,4R)-1-tert-butyl-4-(2...) Show SMILES CC(C)CC(CN(C(C)C)C(C)=O)N1CCN(CC1)C(=O)[C@@H]1CN(C[C@H]1c1ccc(F)cc1F)C(C)(C)C |r| Show InChI InChI=1S/C30H48F2N4O2/c1-20(2)15-24(17-36(21(3)4)22(5)37)33-11-13-34(14-12-33)29(38)27-19-35(30(6,7)8)18-26(27)25-10-9-23(31)16-28(25)32/h9-10,16,20-21,24,26-27H,11-15,17-19H2,1-8H3/t24?,26-,27+/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Displacement of [125I]NDP-alpha-MSH from human MC3 receptor expressed in CHO cells				Bioorg Med Chem Lett 20: 4483-6 (2010) Article DOI: 10.1016/j.bmcl.2010.06.038 BindingDB Entry DOI: 10.7270/Q2C829GJ
					More data for this Ligand-Target Pair
Melanocortin receptor 3 (Homo sapiens (Human))	BDBM50323159 (CHEMBL1209321 | N-(2-(4-((3S,4R)-1-tert-butyl-4-(2...) Show SMILES CC(C)CC(CN(C(C)C)C(C)=O)N1CCN(CC1)C(=O)[C@@H]1CN(C[C@H]1c1ccc(F)cc1F)C(C)(C)C |r| Show InChI InChI=1S/C30H48F2N4O2/c1-20(2)15-24(17-36(21(3)4)22(5)37)33-11-13-34(14-12-33)29(38)27-19-35(30(6,7)8)18-26(27)25-10-9-23(31)16-28(25)32/h9-10,16,20-21,24,26-27H,11-15,17-19H2,1-8H3/t24?,26-,27+/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	880	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Agonist activity at human MC3 receptor expressed in CHO cells assessed as increase of alpha-MSH-induced cAMP accumulation				Bioorg Med Chem Lett 20: 4483-6 (2010) Article DOI: 10.1016/j.bmcl.2010.06.038 BindingDB Entry DOI: 10.7270/Q2C829GJ
					More data for this Ligand-Target Pair
Melanocortin receptor 5 (MC5R) (Homo sapiens (Human))	BDBM50323159 (CHEMBL1209321 | N-(2-(4-((3S,4R)-1-tert-butyl-4-(2...) Show SMILES CC(C)CC(CN(C(C)C)C(C)=O)N1CCN(CC1)C(=O)[C@@H]1CN(C[C@H]1c1ccc(F)cc1F)C(C)(C)C |r| Show InChI InChI=1S/C30H48F2N4O2/c1-20(2)15-24(17-36(21(3)4)22(5)37)33-11-13-34(14-12-33)29(38)27-19-35(30(6,7)8)18-26(27)25-10-9-23(31)16-28(25)32/h9-10,16,20-21,24,26-27H,11-15,17-19H2,1-8H3/t24?,26-,27+/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Displacement of [125I]NDP-alpha-MSH from human MC5 receptor expressed in CHO cells				Bioorg Med Chem Lett 20: 4483-6 (2010) Article DOI: 10.1016/j.bmcl.2010.06.038 BindingDB Entry DOI: 10.7270/Q2C829GJ
					More data for this Ligand-Target Pair
Melanocortin receptor 5 (MC5R) (Homo sapiens (Human))	BDBM50323159 (CHEMBL1209321 | N-(2-(4-((3S,4R)-1-tert-butyl-4-(2...) Show SMILES CC(C)CC(CN(C(C)C)C(C)=O)N1CCN(CC1)C(=O)[C@@H]1CN(C[C@H]1c1ccc(F)cc1F)C(C)(C)C |r| Show InChI InChI=1S/C30H48F2N4O2/c1-20(2)15-24(17-36(21(3)4)22(5)37)33-11-13-34(14-12-33)29(38)27-19-35(30(6,7)8)18-26(27)25-10-9-23(31)16-28(25)32/h9-10,16,20-21,24,26-27H,11-15,17-19H2,1-8H3/t24?,26-,27+/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Agonist activity at human MC5 receptor expressed in CHO cells assessed as increase of alpha-MSH-induced cAMP accumulation				Bioorg Med Chem Lett 20: 4483-6 (2010) Article DOI: 10.1016/j.bmcl.2010.06.038 BindingDB Entry DOI: 10.7270/Q2C829GJ
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50323159 (CHEMBL1209321 | N-(2-(4-((3S,4R)-1-tert-butyl-4-(2...) Show SMILES CC(C)CC(CN(C(C)C)C(C)=O)N1CCN(CC1)C(=O)[C@@H]1CN(C[C@H]1c1ccc(F)cc1F)C(C)(C)C |r| Show InChI InChI=1S/C30H48F2N4O2/c1-20(2)15-24(17-36(21(3)4)22(5)37)33-11-13-34(14-12-33)29(38)27-19-35(30(6,7)8)18-26(27)25-10-9-23(31)16-28(25)32/h9-10,16,20-21,24,26-27H,11-15,17-19H2,1-8H3/t24?,26-,27+/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	49	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Agonist activity at human MC4 receptor expressed in CHO cells assessed as increase of alpha-MSH-induced cAMP accumulation				Bioorg Med Chem Lett 20: 4483-6 (2010) Article DOI: 10.1016/j.bmcl.2010.06.038 BindingDB Entry DOI: 10.7270/Q2C829GJ
					More data for this Ligand-Target Pair
Melanocyte-stimulating hormone receptor (Homo sapiens (Human))	BDBM50323159 (CHEMBL1209321 | N-(2-(4-((3S,4R)-1-tert-butyl-4-(2...) Show SMILES CC(C)CC(CN(C(C)C)C(C)=O)N1CCN(CC1)C(=O)[C@@H]1CN(C[C@H]1c1ccc(F)cc1F)C(C)(C)C |r| Show InChI InChI=1S/C30H48F2N4O2/c1-20(2)15-24(17-36(21(3)4)22(5)37)33-11-13-34(14-12-33)29(38)27-19-35(30(6,7)8)18-26(27)25-10-9-23(31)16-28(25)32/h9-10,16,20-21,24,26-27H,11-15,17-19H2,1-8H3/t24?,26-,27+/m0/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	560	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Agonist activity at human MC1 receptor expressed in CHO cells assessed as increase of alpha-MSH-induced cAMP accumulation				Bioorg Med Chem Lett 20: 4483-6 (2010) Article DOI: 10.1016/j.bmcl.2010.06.038 BindingDB Entry DOI: 10.7270/Q2C829GJ
					More data for this Ligand-Target Pair
Melanocyte-stimulating hormone receptor (Homo sapiens (Human))	BDBM50323159 (CHEMBL1209321 | N-(2-(4-((3S,4R)-1-tert-butyl-4-(2...) Show SMILES CC(C)CC(CN(C(C)C)C(C)=O)N1CCN(CC1)C(=O)[C@@H]1CN(C[C@H]1c1ccc(F)cc1F)C(C)(C)C |r| Show InChI InChI=1S/C30H48F2N4O2/c1-20(2)15-24(17-36(21(3)4)22(5)37)33-11-13-34(14-12-33)29(38)27-19-35(30(6,7)8)18-26(27)25-10-9-23(31)16-28(25)32/h9-10,16,20-21,24,26-27H,11-15,17-19H2,1-8H3/t24?,26-,27+/m0/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Displacement of [125I]NDP-alpha-MSH from human MC1 receptor expressed in CHO cells				Bioorg Med Chem Lett 20: 4483-6 (2010) Article DOI: 10.1016/j.bmcl.2010.06.038 BindingDB Entry DOI: 10.7270/Q2C829GJ
					More data for this Ligand-Target Pair