BDBM50323265 CHEMBL1208847::N-(4-(4-cyano-1H-imidazo[4,5-c]pyridin-6-yl)-2-(trifluoromethyl)phenyl)acetamide

SMILES: CC(=O)Nc1ccc(cc1C(F)(F)F)-c1cc2nc[nH]c2c(n1)C#N

InChI Key: InChIKey=RTYPDZWNEFAGDW-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50323265   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cathepsin S (Homo sapiens (Human))	BDBM50323265 (CHEMBL1208847 | N-(4-(4-cyano-1H-imidazo[4,5-c]pyr...) Show SMILES CC(=O)Nc1ccc(cc1C(F)(F)F)-c1cc2nc[nH]c2c(n1)C#N Show InChI InChI=1S/C16H10F3N5O/c1-8(25)23-11-3-2-9(4-10(11)16(17,18)19)12-5-13-15(22-7-21-13)14(6-20)24-12/h2-5,7H,1H3,(H,21,22)(H,23,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.24E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human cathepsin S by fluorescence assay				Bioorg Med Chem Lett 20: 4350-4 (2010) Article DOI: 10.1016/j.bmcl.2010.06.072 BindingDB Entry DOI: 10.7270/Q2028RR9
					More data for this Ligand-Target Pair
Cathepsin K (Homo sapiens (Human))	BDBM50323265 (CHEMBL1208847 | N-(4-(4-cyano-1H-imidazo[4,5-c]pyr...) Show SMILES CC(=O)Nc1ccc(cc1C(F)(F)F)-c1cc2nc[nH]c2c(n1)C#N Show InChI InChI=1S/C16H10F3N5O/c1-8(25)23-11-3-2-9(4-10(11)16(17,18)19)12-5-13-15(22-7-21-13)14(6-20)24-12/h2-5,7H,1H3,(H,21,22)(H,23,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human cathepsin K by fluorescence assay				Bioorg Med Chem Lett 20: 4350-4 (2010) Article DOI: 10.1016/j.bmcl.2010.06.072 BindingDB Entry DOI: 10.7270/Q2028RR9
					More data for this Ligand-Target Pair