BDBM50323451 CHEMBL1209794::N-(2-((S)-6-chloro-1'-((3S,4R)-4-(2,4-difluorophenyl)-1-(tetrahydro-2H-pyran-4-yl)pyrrolidine-3-carbonyl)-5-methyl-3H-spiro[isobenzofuran-1,4'-piperidine]-3-yl)propan-2-yl)acetamide

SMILES: CC(=O)NC(C)(C)[C@H]1OC2(CCN(CC2)C(=O)[C@@H]2CN(C[C@H]2c2ccc(F)cc2F)C2CCOCC2)c2cc(Cl)c(C)cc12

InChI Key: InChIKey=YYCCWOBZNRVRNZ-PZXMZKPCSA-N

Data: 1 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50323451   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50323451 (CHEMBL1209794 | N-(2-((S)-6-chloro-1'-((3S,4R)-4-(...) Show SMILES CC(=O)NC(C)(C)[C@H]1OC2(CCN(CC2)C(=O)[C@@H]2CN(C[C@H]2c2ccc(F)cc2F)C2CCOCC2)c2cc(Cl)c(C)cc12 |r| Show InChI InChI=1S/C34H42ClF2N3O4/c1-20-15-25-28(17-29(20)35)34(44-31(25)33(3,4)38-21(2)41)9-11-39(12-10-34)32(42)27-19-40(23-7-13-43-14-8-23)18-26(27)24-6-5-22(36)16-30(24)37/h5-6,15-17,23,26-27,31H,7-14,18-19H2,1-4H3,(H,38,41)/t26-,27+,31-/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.20	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Displacement of [125I]NDP-alpha-MSH from human melanocortin 4 receptor expressed in CHO cells				Bioorg Med Chem Lett 20: 4895-900 (2010) Article DOI: 10.1016/j.bmcl.2010.06.068 BindingDB Entry DOI: 10.7270/Q2TB172P
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50323451 (CHEMBL1209794 | N-(2-((S)-6-chloro-1'-((3S,4R)-4-(...) Show SMILES CC(=O)NC(C)(C)[C@H]1OC2(CCN(CC2)C(=O)[C@@H]2CN(C[C@H]2c2ccc(F)cc2F)C2CCOCC2)c2cc(Cl)c(C)cc12 |r| Show InChI InChI=1S/C34H42ClF2N3O4/c1-20-15-25-28(17-29(20)35)34(44-31(25)33(3,4)38-21(2)41)9-11-39(12-10-34)32(42)27-19-40(23-7-13-43-14-8-23)18-26(27)24-6-5-22(36)16-30(24)37/h5-6,15-17,23,26-27,31H,7-14,18-19H2,1-4H3,(H,38,41)/t26-,27+,31-/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	7.40	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Agonist activity at human melanocortin 4 receptor expressed in CHO cells assessed as cAMP release				Bioorg Med Chem Lett 20: 4895-900 (2010) Article DOI: 10.1016/j.bmcl.2010.06.068 BindingDB Entry DOI: 10.7270/Q2TB172P
					More data for this Ligand-Target Pair