BDBM50323736 2-(3-(2-methoxyphenyl)-4-oxo-3,4,5,6,7,8-hexahydroquinazolin-2-ylthio)-N-(quinoxalin-6-yl)acetamide::2-{[3-(2-METHOXYPHENYL)-4-OXO-3,4,5,6,7,8-HEXAHYDROQUINAZOLIN-2-YL]SULFANYL}-N-QUINOXALIN-6-YLACETAMIDE::CHEMBL1213169

SMILES: COc1ccccc1-n1c(SCC(=O)Nc2ccc3nccnc3c2)nc2CCCCc2c1=O

InChI Key: InChIKey=AXVDURNCPXUGDZ-UHFFFAOYSA-N

Data: 5 IC50

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50323736   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM50323736 (2-(3-(2-methoxyphenyl)-4-oxo-3,4,5,6,7,8-hexahydro...) Show SMILES COc1ccccc1-n1c(SCC(=O)Nc2ccc3nccnc3c2)nc2CCCCc2c1=O |(21.65,-14.78,;20.32,-15.55,;20.33,-17.09,;21.66,-17.85,;21.67,-19.4,;20.33,-20.18,;19,-19.41,;19,-17.86,;17.67,-17.1,;17.66,-15.56,;18.99,-14.78,;18.99,-13.24,;20.32,-12.47,;21.66,-13.23,;20.32,-10.93,;21.65,-10.15,;22.98,-10.92,;24.31,-10.14,;24.31,-8.6,;25.64,-7.82,;25.63,-6.28,;24.27,-5.51,;22.94,-6.3,;22.96,-7.84,;21.64,-8.62,;16.33,-14.79,;15.01,-15.56,;13.68,-14.78,;12.35,-15.56,;12.35,-17.1,;13.68,-17.86,;15.01,-17.1,;16.34,-17.87,;16.33,-19.41,)| Show InChI InChI=1S/C25H23N5O3S/c1-33-22-9-5-4-8-21(22)30-24(32)17-6-2-3-7-18(17)29-25(30)34-15-23(31)28-16-10-11-19-20(14-16)27-13-12-26-19/h4-5,8-14H,2-3,6-7,15H2,1H3,(H,28,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	3.44E+3	n/a	n/a	n/a	n/a	n/a	n/a
Medical Research Council-Laboratory of Molecular Biology Curated by ChEMBL					Assay Description Inhibition of p110alpha				Nat Chem Biol 6: 117-24 (2010) Article DOI: 10.1038/nchembio.293 BindingDB Entry DOI: 10.7270/Q2KP82CK
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (Homo sapiens (Human))	BDBM50323736 (2-(3-(2-methoxyphenyl)-4-oxo-3,4,5,6,7,8-hexahydro...) Show SMILES COc1ccccc1-n1c(SCC(=O)Nc2ccc3nccnc3c2)nc2CCCCc2c1=O |(21.65,-14.78,;20.32,-15.55,;20.33,-17.09,;21.66,-17.85,;21.67,-19.4,;20.33,-20.18,;19,-19.41,;19,-17.86,;17.67,-17.1,;17.66,-15.56,;18.99,-14.78,;18.99,-13.24,;20.32,-12.47,;21.66,-13.23,;20.32,-10.93,;21.65,-10.15,;22.98,-10.92,;24.31,-10.14,;24.31,-8.6,;25.64,-7.82,;25.63,-6.28,;24.27,-5.51,;22.94,-6.3,;22.96,-7.84,;21.64,-8.62,;16.33,-14.79,;15.01,-15.56,;13.68,-14.78,;12.35,-15.56,;12.35,-17.1,;13.68,-17.86,;15.01,-17.1,;16.34,-17.87,;16.33,-19.41,)| Show InChI InChI=1S/C25H23N5O3S/c1-33-22-9-5-4-8-21(22)30-24(32)17-6-2-3-7-18(17)29-25(30)34-15-23(31)28-16-10-11-19-20(14-16)27-13-12-26-19/h4-5,8-14H,2-3,6-7,15H2,1H3,(H,28,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	4.23E+3	n/a	n/a	n/a	n/a	n/a	n/a
Medical Research Council-Laboratory of Molecular Biology Curated by ChEMBL					Assay Description Inhibition of p110beta				Nat Chem Biol 6: 117-24 (2010) Article DOI: 10.1038/nchembio.293 BindingDB Entry DOI: 10.7270/Q2KP82CK
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM50323736 (2-(3-(2-methoxyphenyl)-4-oxo-3,4,5,6,7,8-hexahydro...) Show SMILES COc1ccccc1-n1c(SCC(=O)Nc2ccc3nccnc3c2)nc2CCCCc2c1=O |(21.65,-14.78,;20.32,-15.55,;20.33,-17.09,;21.66,-17.85,;21.67,-19.4,;20.33,-20.18,;19,-19.41,;19,-17.86,;17.67,-17.1,;17.66,-15.56,;18.99,-14.78,;18.99,-13.24,;20.32,-12.47,;21.66,-13.23,;20.32,-10.93,;21.65,-10.15,;22.98,-10.92,;24.31,-10.14,;24.31,-8.6,;25.64,-7.82,;25.63,-6.28,;24.27,-5.51,;22.94,-6.3,;22.96,-7.84,;21.64,-8.62,;16.33,-14.79,;15.01,-15.56,;13.68,-14.78,;12.35,-15.56,;12.35,-17.1,;13.68,-17.86,;15.01,-17.1,;16.34,-17.87,;16.33,-19.41,)| Show InChI InChI=1S/C25H23N5O3S/c1-33-22-9-5-4-8-21(22)30-24(32)17-6-2-3-7-18(17)29-25(30)34-15-23(31)28-16-10-11-19-20(14-16)27-13-12-26-19/h4-5,8-14H,2-3,6-7,15H2,1H3,(H,28,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem	MMDB PDB Article PubMed	n/a	n/a	34	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of PI3Kdelta				J Med Chem 55: 8559-81 (2012) Article DOI: 10.1021/jm300847w BindingDB Entry DOI: 10.7270/Q2SN0B47
					More data for this Ligand-Target Pair				3D Structure (crystal)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM50323736 (2-(3-(2-methoxyphenyl)-4-oxo-3,4,5,6,7,8-hexahydro...) Show SMILES COc1ccccc1-n1c(SCC(=O)Nc2ccc3nccnc3c2)nc2CCCCc2c1=O |(21.65,-14.78,;20.32,-15.55,;20.33,-17.09,;21.66,-17.85,;21.67,-19.4,;20.33,-20.18,;19,-19.41,;19,-17.86,;17.67,-17.1,;17.66,-15.56,;18.99,-14.78,;18.99,-13.24,;20.32,-12.47,;21.66,-13.23,;20.32,-10.93,;21.65,-10.15,;22.98,-10.92,;24.31,-10.14,;24.31,-8.6,;25.64,-7.82,;25.63,-6.28,;24.27,-5.51,;22.94,-6.3,;22.96,-7.84,;21.64,-8.62,;16.33,-14.79,;15.01,-15.56,;13.68,-14.78,;12.35,-15.56,;12.35,-17.1,;13.68,-17.86,;15.01,-17.1,;16.34,-17.87,;16.33,-19.41,)| Show InChI InChI=1S/C25H23N5O3S/c1-33-22-9-5-4-8-21(22)30-24(32)17-6-2-3-7-18(17)29-25(30)34-15-23(31)28-16-10-11-19-20(14-16)27-13-12-26-19/h4-5,8-14H,2-3,6-7,15H2,1H3,(H,28,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem	MMDB PDB Article PubMed	n/a	n/a	34	n/a	n/a	n/a	n/a	n/a	n/a
Medical Research Council-Laboratory of Molecular Biology Curated by ChEMBL					Assay Description Inhibition of p110delta				Nat Chem Biol 6: 117-24 (2010) Article DOI: 10.1038/nchembio.293 BindingDB Entry DOI: 10.7270/Q2KP82CK
					More data for this Ligand-Target Pair				3D Structure (crystal)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Homo sapiens (Human))	BDBM50323736 (2-(3-(2-methoxyphenyl)-4-oxo-3,4,5,6,7,8-hexahydro...) Show SMILES COc1ccccc1-n1c(SCC(=O)Nc2ccc3nccnc3c2)nc2CCCCc2c1=O |(21.65,-14.78,;20.32,-15.55,;20.33,-17.09,;21.66,-17.85,;21.67,-19.4,;20.33,-20.18,;19,-19.41,;19,-17.86,;17.67,-17.1,;17.66,-15.56,;18.99,-14.78,;18.99,-13.24,;20.32,-12.47,;21.66,-13.23,;20.32,-10.93,;21.65,-10.15,;22.98,-10.92,;24.31,-10.14,;24.31,-8.6,;25.64,-7.82,;25.63,-6.28,;24.27,-5.51,;22.94,-6.3,;22.96,-7.84,;21.64,-8.62,;16.33,-14.79,;15.01,-15.56,;13.68,-14.78,;12.35,-15.56,;12.35,-17.1,;13.68,-17.86,;15.01,-17.1,;16.34,-17.87,;16.33,-19.41,)| Show InChI InChI=1S/C25H23N5O3S/c1-33-22-9-5-4-8-21(22)30-24(32)17-6-2-3-7-18(17)29-25(30)34-15-23(31)28-16-10-11-19-20(14-16)27-13-12-26-19/h4-5,8-14H,2-3,6-7,15H2,1H3,(H,28,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Medical Research Council-Laboratory of Molecular Biology Curated by ChEMBL					Assay Description Inhibition of p110gamma				Nat Chem Biol 6: 117-24 (2010) Article DOI: 10.1038/nchembio.293 BindingDB Entry DOI: 10.7270/Q2KP82CK
					More data for this Ligand-Target Pair