BDBM50324275 (Z)-5-(Indolin-1-ylsulfonyl)-3-{[3-(3-morpholino-3-oxopropyl)-4-oxo-4,5,6,7-tetrahydro-1H-indol-2-yl]methylene}indolin-2-one::CHEMBL1215283

SMILES: O=C(CCc1c(C=C2C(=O)Nc3ccc(cc23)S(=O)(=O)N2CCc3ccccc23)[nH]c2CCCC(=O)c12)N1CCOCC1

InChI Key: InChIKey=HMUZWZQGRIJSCT-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50324275   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Aurora kinase A (Homo sapiens (Human))	BDBM50324275 ((Z)-5-(Indolin-1-ylsulfonyl)-3-{[3-(3-morpholino-3...) Show SMILES O=C(CCc1c(C=C2C(=O)Nc3ccc(cc23)S(=O)(=O)N2CCc3ccccc23)[nH]c2CCCC(=O)c12)N1CCOCC1 |w:6.5| Show InChI InChI=1S/C32H32N4O6S/c37-29-7-3-5-26-31(29)22(9-11-30(38)35-14-16-42-17-15-35)27(33-26)19-24-23-18-21(8-10-25(23)34-32(24)39)43(40,41)36-13-12-20-4-1-2-6-28(20)36/h1-2,4,6,8,10,18-19,33H,3,5,7,9,11-17H2,(H,34,39)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	563	n/a	n/a	n/a	n/a	n/a	n/a
Development Center for Biotechnology Curated by ChEMBL					Assay Description Inhibition of recombinant aurora A				J Med Chem 53: 5929-41 (2010) Article DOI: 10.1021/jm1001869 BindingDB Entry DOI: 10.7270/Q2XS5VKS
					More data for this Ligand-Target Pair
Aurora kinase B (Homo sapiens (Human))	BDBM50324275 ((Z)-5-(Indolin-1-ylsulfonyl)-3-{[3-(3-morpholino-3...) Show SMILES O=C(CCc1c(C=C2C(=O)Nc3ccc(cc23)S(=O)(=O)N2CCc3ccccc23)[nH]c2CCCC(=O)c12)N1CCOCC1 |w:6.5| Show InChI InChI=1S/C32H32N4O6S/c37-29-7-3-5-26-31(29)22(9-11-30(38)35-14-16-42-17-15-35)27(33-26)19-24-23-18-21(8-10-25(23)34-32(24)39)43(40,41)36-13-12-20-4-1-2-6-28(20)36/h1-2,4,6,8,10,18-19,33H,3,5,7,9,11-17H2,(H,34,39)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.15E+3	n/a	n/a	n/a	n/a	n/a	n/a
Development Center for Biotechnology Curated by ChEMBL					Assay Description Inhibition of recombinant aurora B				J Med Chem 53: 5929-41 (2010) Article DOI: 10.1021/jm1001869 BindingDB Entry DOI: 10.7270/Q2XS5VKS
					More data for this Ligand-Target Pair