null

SMILES: COC(=O)c1cccc(\C=C\c2nc3ccc(OC)cc3c(=O)n2-c2ccc(cc2)C(O)=O)c1

InChI Key: InChIKey=UEOQWFSGDDLBLM-AWNIVKPZSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50324417   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glutamate receptor 1 (Rattus norvegicus (Rat))	BDBM50324417 ((E)-4-(6,7-Dimethoxy-2-(3-nitrostyryl)-4-oxoquinaz...) Show SMILES COC(=O)c1cccc(\C=C\c2nc3ccc(OC)cc3c(=O)n2-c2ccc(cc2)C(O)=O)c1 Show InChI InChI=1S/C26H20N2O6/c1-33-20-11-12-22-21(15-20)24(29)28(19-9-7-17(8-10-19)25(30)31)23(27-22)13-6-16-4-3-5-18(14-16)26(32)34-2/h3-15H,1-2H3,(H,30,31)/b13-6+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Emory University Curated by ChEMBL					Assay Description Antagonist activity at rat recombinant GLuR1 expressed in Xenopus oocytes assessed as inhibition of glutamate-induced current by two-electrode voltag...				J Med Chem 53: 5476-90 (2010) Article DOI: 10.1021/jm100027p BindingDB Entry DOI: 10.7270/Q2DR2VQF
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2C (RAT-Rattus norvegicus (Rat))	BDBM50324417 ((E)-4-(6,7-Dimethoxy-2-(3-nitrostyryl)-4-oxoquinaz...) Show SMILES COC(=O)c1cccc(\C=C\c2nc3ccc(OC)cc3c(=O)n2-c2ccc(cc2)C(O)=O)c1 Show InChI InChI=1S/C26H20N2O6/c1-33-20-11-12-22-21(15-20)24(29)28(19-9-7-17(8-10-19)25(30)31)23(27-22)13-6-16-4-3-5-18(14-16)26(32)34-2/h3-15H,1-2H3,(H,30,31)/b13-6+	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Emory University Curated by ChEMBL					Assay Description Antagonist activity at rat recombinant NR1-NR2C receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...				J Med Chem 53: 5476-90 (2010) Article DOI: 10.1021/jm100027p BindingDB Entry DOI: 10.7270/Q2DR2VQF
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2A (Rattus norvegicus (Rat)-RAT)	BDBM50324417 ((E)-4-(6,7-Dimethoxy-2-(3-nitrostyryl)-4-oxoquinaz...) Show SMILES COC(=O)c1cccc(\C=C\c2nc3ccc(OC)cc3c(=O)n2-c2ccc(cc2)C(O)=O)c1 Show InChI InChI=1S/C26H20N2O6/c1-33-20-11-12-22-21(15-20)24(29)28(19-9-7-17(8-10-19)25(30)31)23(27-22)13-6-16-4-3-5-18(14-16)26(32)34-2/h3-15H,1-2H3,(H,30,31)/b13-6+	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Emory University Curated by ChEMBL					Assay Description Antagonist activity at rat recombinant NR1-NR2A receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...				J Med Chem 53: 5476-90 (2010) Article DOI: 10.1021/jm100027p BindingDB Entry DOI: 10.7270/Q2DR2VQF
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B (Rattus norvegicus (Rat)-RAT)	BDBM50324417 ((E)-4-(6,7-Dimethoxy-2-(3-nitrostyryl)-4-oxoquinaz...) Show SMILES COC(=O)c1cccc(\C=C\c2nc3ccc(OC)cc3c(=O)n2-c2ccc(cc2)C(O)=O)c1 Show InChI InChI=1S/C26H20N2O6/c1-33-20-11-12-22-21(15-20)24(29)28(19-9-7-17(8-10-19)25(30)31)23(27-22)13-6-16-4-3-5-18(14-16)26(32)34-2/h3-15H,1-2H3,(H,30,31)/b13-6+	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
Emory University Curated by ChEMBL					Assay Description Antagonist activity at rat recombinant NR1-NR2B receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...				J Med Chem 53: 5476-90 (2010) Article DOI: 10.1021/jm100027p BindingDB Entry DOI: 10.7270/Q2DR2VQF
					More data for this Ligand-Target Pair