BDBM50324588 2-Amino-2-(4-chlorophenyl)-N-(2-(2-(dimethylamino)ethoxy)-4-(1H-pyrazol-4-yl)phenyl)aceta-mide::CHEMBL1215023

SMILES: CN(C)CCOc1cc(ccc1NC(=O)C(N)c1ccc(Cl)cc1)-c1cn[nH]c1

InChI Key: InChIKey=WFSCKXAZYAROMK-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50324588   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50324588 (2-Amino-2-(4-chlorophenyl)-N-(2-(2-(dimethylamino)...) Show SMILES CN(C)CCOc1cc(ccc1NC(=O)C(N)c1ccc(Cl)cc1)-c1cn[nH]c1 Show InChI InChI=1S/C21H24ClN5O2/c1-27(2)9-10-29-19-11-15(16-12-24-25-13-16)5-8-18(19)26-21(28)20(23)14-3-6-17(22)7-4-14/h3-8,11-13,20H,9-10,23H2,1-2H3,(H,24,25)(H,26,28)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of ROCK2				J Med Chem 53: 5727-37 (2010) Article DOI: 10.1021/jm100579r BindingDB Entry DOI: 10.7270/Q2833S8C
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50324588 (2-Amino-2-(4-chlorophenyl)-N-(2-(2-(dimethylamino)...) Show SMILES CN(C)CCOc1cc(ccc1NC(=O)C(N)c1ccc(Cl)cc1)-c1cn[nH]c1 Show InChI InChI=1S/C21H24ClN5O2/c1-27(2)9-10-29-19-11-15(16-12-24-25-13-16)5-8-18(19)26-21(28)20(23)14-3-6-17(22)7-4-14/h3-8,11-13,20H,9-10,23H2,1-2H3,(H,24,25)(H,26,28)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	310	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assay				J Med Chem 53: 5727-37 (2010) Article DOI: 10.1021/jm100579r BindingDB Entry DOI: 10.7270/Q2833S8C
					More data for this Ligand-Target Pair