BDBM50324734 7,9-Dimethyl-6-(5-methyl-furan-2-yl)-11-phenyl-6,7-dihydro-5H-5,7,9,11a-tetraaza-benzo[a]fluorene-8,10-dione::CHEMBL1087004
SMILES: Cc1ccc(o1)C1Nc2ccccc2-n2c1c1n(C)c(=O)n(C)c(=O)c1c2-c1ccccc1
InChI Key: InChIKey=MNOOVRNGPIWJDI-UHFFFAOYSA-N
Data: 6 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human)) | BDBM50324734 (7,9-Dimethyl-6-(5-methyl-furan-2-yl)-11-phenyl-6,7...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | <1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California Curated by ChEMBL | Assay Description Inhibition of CFTR in nonpermeabilized human T84 cells assessed as inhibition of forskolin and IBMX-induced chloride current by short-circuit current... | J Med Chem 52: 6447-55 (2009) Article DOI: 10.1021/jm9009873 BindingDB Entry DOI: 10.7270/Q28W3DHW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human)) | BDBM50324734 (7,9-Dimethyl-6-(5-methyl-furan-2-yl)-11-phenyl-6,7...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California Curated by ChEMBL | Assay Description Inhibition of human CFTR expressed in rat FRT cells assessed as inhibition of CPT-cAMP-induced apical membrane current in presence of transepithelial... | J Med Chem 52: 6447-55 (2009) Article DOI: 10.1021/jm9009873 BindingDB Entry DOI: 10.7270/Q28W3DHW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human)) | BDBM50324734 (7,9-Dimethyl-6-(5-methyl-furan-2-yl)-11-phenyl-6,7...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 800 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California Curated by ChEMBL | Assay Description Inhibition of human CFTR expressed in rat FRT cells coexpressing halide indicator YFP-H148Q assessed as inhibition of halide influx preincubated for ... | J Med Chem 52: 6447-55 (2009) Article DOI: 10.1021/jm9009873 BindingDB Entry DOI: 10.7270/Q28W3DHW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human)) | BDBM50324734 (7,9-Dimethyl-6-(5-methyl-furan-2-yl)-11-phenyl-6,7...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 250 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California Curated by ChEMBL | Assay Description Inhibition of human wild-type CFTR expressed in FRT cells coexpressing YFP-H148Q assessed as inhibition of cAMP agonist-induced iodide influx after 4... | J Med Chem 54: 5468-77 (2011) Article DOI: 10.1021/jm200505e BindingDB Entry DOI: 10.7270/Q2280809 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human)) | BDBM50324734 (7,9-Dimethyl-6-(5-methyl-furan-2-yl)-11-phenyl-6,7...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California Curated by ChEMBL | Assay Description Inhibition of human wild-type CFTR expressed in FRT cells assessed as inhibition of forskolin-induced short-circuit current by voltage clamp electrop... | J Med Chem 54: 5468-77 (2011) Article DOI: 10.1021/jm200505e BindingDB Entry DOI: 10.7270/Q2280809 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human)) | BDBM50324734 (7,9-Dimethyl-6-(5-methyl-furan-2-yl)-11-phenyl-6,7...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | <1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California Curated by ChEMBL | Assay Description Inhibition of CFTR in nonpermeabilized human bronchial epithelial cells assessed as inhibition of forskolin and IBMX-induced chloride current at by s... | J Med Chem 52: 6447-55 (2009) Article DOI: 10.1021/jm9009873 BindingDB Entry DOI: 10.7270/Q28W3DHW | |||||||||||
More data for this Ligand-Target Pair |