BDBM50324924 (S)-3-(2-amino-5-chloro-1H-benzo[d]imidazol-1-yl)-N-((tetrahydro-2H-pyran-4-yl)methyl)pentanamide::CHEMBL1222298

SMILES: CC[C@@H](CC(=O)NCC1CCOCC1)n1c(N)nc2cc(Cl)ccc12

InChI Key: InChIKey=MGDIYBDWQLFUQN-AWEZNQCLSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50324924   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Beta-secretase 1 (Homo sapiens (Human))	BDBM50324924 ((S)-3-(2-amino-5-chloro-1H-benzo[d]imidazol-1-yl)-...) Show SMILES CC[C@@H](CC(=O)NCC1CCOCC1)n1c(N)nc2cc(Cl)ccc12 |r| Show InChI InChI=1S/C18H25ClN4O2/c1-2-14(10-17(24)21-11-12-5-7-25-8-6-12)23-16-4-3-13(19)9-15(16)22-18(23)20/h3-4,9,12,14H,2,5-8,10-11H2,1H3,(H2,20,22)(H,21,24)/t14-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
Evotec UK Ltd Curated by ChEMBL					Assay Description Inhibition of BACE1 assessed as amyloid beta secretion by cell based assay				Bioorg Med Chem Lett 20: 5329-33 (2010) Article DOI: 10.1016/j.bmcl.2010.06.089 BindingDB Entry DOI: 10.7270/Q2VQ32W7
					More data for this Ligand-Target Pair