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SMILES: CCNC(=O)c1ccc(cc1)-c1ccc2c(C)cc3n[nH]c(=O)n3c2c1

InChI Key: InChIKey=NAHKUGXSCFOSQJ-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50325158   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))		BDBM50325158
PNG
(CHEMBL1223317 | N-ethyl-4-(5-methyl-1-oxo-1,2-dihy...)
Show SMILES CCNC(=O)c1ccc(cc1)-c1ccc2c(C)cc3n[nH]c(=O)n3c2c1
Show InChI InChI=1S/C20H18N4O2/c1-3-21-19(25)14-6-4-13(5-7-14)15-8-9-16-12(2)10-18-22-23-20(26)24(18)17(16)11-15/h4-11H,3H2,1-2H3,(H,21,25)(H,23,26)
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Article
PubMed
n/an/a 20n/an/an/an/an/an/a



AstraZeneca R&D Boston

Curated by ChEMBL


Assay Description
Inhibition of His6-CHK1 expressed in baculovirus infected Sf9 cells

Bioorg Med Chem Lett 20: 5133-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.015
BindingDB Entry DOI: 10.7270/Q2FF3SJZ
More data for this
Ligand-Target Pair