BDBM50325162 5-methyl-8-(3-(piperazin-1-ylmethyl)phenyl)-[1,2,4]triazolo[4,3-a]quinolin-1(2H)-one::CHEMBL1223321

SMILES: Cc1cc2n[nH]c(=O)n2c2cc(ccc12)-c1cccc(CN2CCNCC2)c1

InChI Key: InChIKey=XKYDSGQTSKYYNE-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50325162   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM50325162 (5-methyl-8-(3-(piperazin-1-ylmethyl)phenyl)-[1,2,4...) Show SMILES Cc1cc2n[nH]c(=O)n2c2cc(ccc12)-c1cccc(CN2CCNCC2)c1 Show InChI InChI=1S/C22H23N5O/c1-15-11-21-24-25-22(28)27(21)20-13-18(5-6-19(15)20)17-4-2-3-16(12-17)14-26-9-7-23-8-10-26/h2-6,11-13,23H,7-10,14H2,1H3,(H,25,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca R&D Boston Curated by ChEMBL					Assay Description Inhibition of His6-CHK1 expressed in baculovirus infected Sf9 cells				Bioorg Med Chem Lett 20: 5133-8 (2010) Article DOI: 10.1016/j.bmcl.2010.07.015 BindingDB Entry DOI: 10.7270/Q2FF3SJZ
					More data for this Ligand-Target Pair