BDBM50325403 (S)-4-(6-(cyclopropylamino)imidazo[1,2-b]pyridazin-3-yl)-N-(pyrrolidin-2-ylmethyl)benzamide::CHEMBL1222929

SMILES: O=C(NC[C@@H]1CCCN1)c1ccc(cc1)-c1cnc2ccc(NC3CC3)nn12

InChI Key: InChIKey=YPTGGZAVFWQNCY-KRWDZBQOSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50325403   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Inhibitor of nuclear factor kappa-B kinase subunit beta (Homo sapiens (Human))	BDBM50325403 ((S)-4-(6-(cyclopropylamino)imidazo[1,2-b]pyridazin...) Show SMILES O=C(NC[C@@H]1CCCN1)c1ccc(cc1)-c1cnc2ccc(NC3CC3)nn12 |r| Show InChI InChI=1S/C21H24N6O/c28-21(24-12-17-2-1-11-22-17)15-5-3-14(4-6-15)18-13-23-20-10-9-19(26-27(18)20)25-16-7-8-16/h3-6,9-10,13,16-17,22H,1-2,7-8,11-12H2,(H,24,28)(H,25,26)/t17-/m0/s1	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Co., Ltd Curated by ChEMBL					Assay Description Inhibition of purified His-tagged IKK-beta after 15 mins				Bioorg Med Chem Lett 20: 5113-8 (2010) Article DOI: 10.1016/j.bmcl.2010.07.026 BindingDB Entry DOI: 10.7270/Q2513ZDM
					More data for this Ligand-Target Pair