BDBM50325432 (R)-2-amino-N-(7-chloro-1-oxo-1,2-dihydroisoquinolin-6-yl)-3-methylbutanamide::CHEMBL1223499

SMILES: CC(C)[C@@H](N)C(=O)Nc1cc2cc[nH]c(=O)c2cc1Cl

InChI Key: InChIKey=WXRZSOWZRRRJSB-GFCCVEGCSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50325432   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50325432 ((R)-2-amino-N-(7-chloro-1-oxo-1,2-dihydroisoquinol...) Show SMILES CC(C)[C@@H](N)C(=O)Nc1cc2cc[nH]c(=O)c2cc1Cl |r| Show InChI InChI=1S/C14H16ClN3O2/c1-7(2)12(16)14(20)18-11-5-8-3-4-17-13(19)9(8)6-10(11)15/h3-7,12H,16H2,1-2H3,(H,17,19)(H,18,20)/t12-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	240	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of ROCK2				Bioorg Med Chem Lett 20: 5153-6 (2010) Article DOI: 10.1016/j.bmcl.2010.07.014 BindingDB Entry DOI: 10.7270/Q2RR1ZDC
					More data for this Ligand-Target Pair