BDBM50325440 (R)-N-(7-chloro-1-oxo-1,2-dihydroisoquinolin-6-yl)pyrrolidine-2-carboxamide::CHEMBL1222482

SMILES: Clc1cc2c(cc[nH]c2=O)cc1NC(=O)[C@H]1CCCN1

InChI Key: InChIKey=ASOKPJKABROLOA-LLVKDONJSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50325440   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50325440 ((R)-N-(7-chloro-1-oxo-1,2-dihydroisoquinolin-6-yl)...) Show SMILES Clc1cc2c(cc[nH]c2=O)cc1NC(=O)[C@H]1CCCN1 |r| Show InChI InChI=1S/C14H14ClN3O2/c15-10-7-9-8(3-5-17-13(9)19)6-12(10)18-14(20)11-2-1-4-16-11/h3,5-7,11,16H,1-2,4H2,(H,17,19)(H,18,20)/t11-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	130	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of ROCK2				Bioorg Med Chem Lett 20: 5153-6 (2010) Article DOI: 10.1016/j.bmcl.2010.07.014 BindingDB Entry DOI: 10.7270/Q2RR1ZDC
					More data for this Ligand-Target Pair