BDBM50325738 (R)-N-((6-chloro-4'-(trifluoromethyl)biphenyl-3-yl)methyl)-1-(3-methoxyphenyl)ethanamine::CHEMBL1224344

SMILES: COc1cccc(c1)[C@@H](C)NCc1ccc(Cl)c(c1)-c1ccc(cc1)C(F)(F)F

InChI Key: InChIKey=DYTWTDGDADYCBL-OAHLLOKOSA-N

Data: 2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50325738   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Calcium-sensing receptor (CaSR) (Homo sapiens (Human))	BDBM50325738 ((R)-N-((6-chloro-4'-(trifluoromethyl)biphenyl-3-yl...) Show SMILES COc1cccc(c1)[C@@H](C)NCc1ccc(Cl)c(c1)-c1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C23H21ClF3NO/c1-15(18-4-3-5-20(13-18)29-2)28-14-16-6-11-22(24)21(12-16)17-7-9-19(10-8-17)23(25,26)27/h3-13,15,28H,14H2,1-2H3/t15-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Positive allosteric modulation of calcium sensing receptor by FLIPR assay in absence of extracellular calcium				Bioorg Med Chem Lett 20: 5544-7 (2010) Article DOI: 10.1016/j.bmcl.2010.07.060 BindingDB Entry DOI: 10.7270/Q2Z89CM3
					More data for this Ligand-Target Pair
Calcium-sensing receptor (CaSR) (Homo sapiens (Human))	BDBM50325738 ((R)-N-((6-chloro-4'-(trifluoromethyl)biphenyl-3-yl...) Show SMILES COc1cccc(c1)[C@@H](C)NCc1ccc(Cl)c(c1)-c1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C23H21ClF3NO/c1-15(18-4-3-5-20(13-18)29-2)28-14-16-6-11-22(24)21(12-16)17-7-9-19(10-8-17)23(25,26)27/h3-13,15,28H,14H2,1-2H3/t15-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	280	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Positive allosteric modulation of calcium sensing receptor by FLIPR assay in presence of extracellular calcium				Bioorg Med Chem Lett 20: 5544-7 (2010) Article DOI: 10.1016/j.bmcl.2010.07.060 BindingDB Entry DOI: 10.7270/Q2Z89CM3
					More data for this Ligand-Target Pair