null
SMILES: FC(F)(F)c1cccc(c1)N1CCN(CCCCNc2nccc3ccccc23)CC1
InChI Key: InChIKey=KFWSEMIBLPIBOC-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
D(2) dopamine receptor (Homo sapiens (Human)) | BDBM50325748 (CHEMBL1223750 | N-(4-(4-(3-(trifluoromethyl)phenyl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Université de Rennes I Curated by ChEMBL | Assay Description Displacement of [3H]spiperone from human dopamine D2S receptor expressed in HEK293 cells | Bioorg Med Chem Lett 20: 5376-9 (2010) Article DOI: 10.1016/j.bmcl.2010.07.096 BindingDB Entry DOI: 10.7270/Q2TH8MXT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(3) dopamine receptor (Homo sapiens (Human)) | BDBM50325748 (CHEMBL1223750 | N-(4-(4-(3-(trifluoromethyl)phenyl...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bioprojet-Biotech Curated by ChEMBL | Assay Description Antagonist activity at D3 receptor (unknown origin) | Eur J Med Chem 125: 565-572 (2017) Article DOI: 10.1016/j.ejmech.2016.09.074 BindingDB Entry DOI: 10.7270/Q20C4Z66 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H4 receptor (Homo sapiens (Human)) | BDBM50325748 (CHEMBL1223750 | N-(4-(4-(3-(trifluoromethyl)phenyl...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 5.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bioprojet-Biotech Curated by ChEMBL | Assay Description Antagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta s... | Eur J Med Chem 125: 565-572 (2017) Article DOI: 10.1016/j.ejmech.2016.09.074 BindingDB Entry DOI: 10.7270/Q20C4Z66 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H4 receptor (Homo sapiens (Human)) | BDBM50325748 (CHEMBL1223750 | N-(4-(4-(3-(trifluoromethyl)phenyl...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 5.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bioprojet-Biotech Curated by ChEMBL | Assay Description Antagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta s... | Eur J Med Chem 125: 565-572 (2017) Article DOI: 10.1016/j.ejmech.2016.09.074 BindingDB Entry DOI: 10.7270/Q20C4Z66 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(3) dopamine receptor (Homo sapiens (Human)) | BDBM50325748 (CHEMBL1223750 | N-(4-(4-(3-(trifluoromethyl)phenyl...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 58 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Université de Rennes I Curated by ChEMBL | Assay Description Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cells | Bioorg Med Chem Lett 20: 5376-9 (2010) Article DOI: 10.1016/j.bmcl.2010.07.096 BindingDB Entry DOI: 10.7270/Q2TH8MXT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-1A adrenergic receptor (Homo sapiens (Human)) | BDBM50325748 (CHEMBL1223750 | N-(4-(4-(3-(trifluoromethyl)phenyl...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 68 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Université de Rennes I Curated by ChEMBL | Assay Description Displacement of [3H]prazosin from human adrenergic alpha1A receptor | Bioorg Med Chem Lett 20: 5376-9 (2010) Article DOI: 10.1016/j.bmcl.2010.07.096 BindingDB Entry DOI: 10.7270/Q2TH8MXT | |||||||||||
More data for this Ligand-Target Pair |