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SMILES: COc1ccc-2c(c1)\C(=N/OCCCN(C)C)c1c-2c(=O)[nH]c2ccccc12

InChI Key: InChIKey=HJUYVUAGVKWJOF-DARPEHSRSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50326182   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
DNA topoisomerase 1


(Homo sapiens (Human))		BDBM50326182
PNG
((E)-6-Hydroxy-9-methoxy-11H-indeno[1,2-c]quinolin-...)
Show SMILES COc1ccc-2c(c1)\C(=N/OCCCN(C)C)c1c-2c(=O)[nH]c2ccccc12
Show InChI InChI=1S/C22H23N3O3/c1-25(2)11-6-12-28-24-21-17-13-14(27-3)9-10-15(17)20-19(21)16-7-4-5-8-18(16)23-22(20)26/h4-5,7-10,13H,6,11-12H2,1-3H3,(H,23,26)/b24-21+
PDB

UniProtKB/SwissProt

antibodypedia
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PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Kaohsiung Medical University

Curated by ChEMBL


Assay Description
Inhibition of human topoisomerase 1 assessed as decrease in pBR322 mobility on agarose gel by electrophoresis

J Med Chem 53: 6164-79 (2010)


Article DOI: 10.1021/jm1005447
BindingDB Entry DOI: 10.7270/Q2BZ6710
More data for this
Ligand-Target Pair