new BindingDB logo
myBDB logout

BDBM50326183 (E)-9-Methoxy-11H-indeno[1,2-c]quinolin-11-oneO-2-morpholinoethyl Oxime::CHEMBL1243166

SMILES: COc1ccc-2c(c1)\C(=N/OCCN1CCOCC1)c1c-2cnc2ccccc12

InChI Key: InChIKey=GIWGKTSIJNHCRG-WJTDDFOZSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50326183   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
DNA topoisomerase I (Topo I)


(Homo sapiens (Human))
BDBM50326183
PNG
((E)-9-Methoxy-11H-indeno[1,2-c]quinolin-11-oneO-2-...)
Show SMILES COc1ccc-2c(c1)\C(=N/OCCN1CCOCC1)c1c-2cnc2ccccc12
Show InChI InChI=1S/C23H23N3O3/c1-27-16-6-7-17-19(14-16)23(25-29-13-10-26-8-11-28-12-9-26)22-18-4-2-3-5-21(18)24-15-20(17)22/h2-7,14-15H,8-13H2,1H3/b25-23+
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Kaohsiung Medical University

Curated by ChEMBL


Assay Description
Inhibition of human topoisomerase 1 assessed as decrease in pBR322 mobility on agarose gel by electrophoresis


J Med Chem 53: 6164-79 (2010)


Article DOI: 10.1021/jm1005447
BindingDB Entry DOI: 10.7270/Q2BZ6710
More data for this
Ligand-Target Pair