BDBM50326183 (E)-9-Methoxy-11H-indeno[1,2-c]quinolin-11-oneO-2-morpholinoethyl Oxime::CHEMBL1243166

SMILES: COc1ccc-2c(c1)\C(=N/OCCN1CCOCC1)c1c-2cnc2ccccc12

InChI Key: InChIKey=GIWGKTSIJNHCRG-WJTDDFOZSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50326183   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
DNA topoisomerase I (Topo I) (Homo sapiens (Human))	BDBM50326183 ((E)-9-Methoxy-11H-indeno[1,2-c]quinolin-11-oneO-2-...) Show SMILES COc1ccc-2c(c1)\C(=N/OCCN1CCOCC1)c1c-2cnc2ccccc12 Show InChI InChI=1S/C23H23N3O3/c1-27-16-6-7-17-19(14-16)23(25-29-13-10-26-8-11-28-12-9-26)22-18-4-2-3-5-21(18)24-15-20(17)22/h2-7,14-15H,8-13H2,1H3/b25-23+	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Kaohsiung Medical University Curated by ChEMBL					Assay Description Inhibition of human topoisomerase 1 assessed as decrease in pBR322 mobility on agarose gel by electrophoresis				J Med Chem 53: 6164-79 (2010) Article DOI: 10.1021/jm1005447 BindingDB Entry DOI: 10.7270/Q2BZ6710
					More data for this Ligand-Target Pair