BDBM50326985 3,3'-((2Z,2'Z)-4,4'-(3,4-dimethoxyphenethylazanediyl)bis(but-2-ene-4,1-diyl))bis(7,8-dimethoxy-1H-benzo[d]azepin-2(3H)-one)::CHEMBL1253477

SMILES: COc1ccc(CCN(C\C=C/CN2C=Cc3cc(OC)c(OC)cc3CC2=O)C\C=C/CN2C=Cc3cc(OC)c(OC)cc3CC2=O)cc1OC

InChI Key: InChIKey=HYAMGVKMAKVYBM-XOHWUJONSA-N

Data: 3 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50326985   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Mus musculus)	BDBM50326985 (3,3'-((2Z,2'Z)-4,4'-(3,4-dimethoxyphenethylazanedi...) Show SMILES COc1ccc(CCN(C\C=C/CN2C=Cc3cc(OC)c(OC)cc3CC2=O)C\C=C/CN2C=Cc3cc(OC)c(OC)cc3CC2=O)cc1OC |c:14,36| Show InChI InChI=1S/C42H49N3O8/c1-48-35-12-11-30(23-36(35)49-2)13-20-43(16-7-9-18-44-21-14-31-24-37(50-3)39(52-5)26-33(31)28-41(44)46)17-8-10-19-45-22-15-32-25-38(51-4)40(53-6)27-34(32)29-42(45)47/h7-12,14-15,21-27H,13,16-20,28-29H2,1-6H3/b9-7-,10-8-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.47E+5	n/a	n/a	n/a	n/a
Laboratory of Design, Synthesis, and Study of Biologically Active Heterocycles (HeteroBioLab) Curated by ChEMBL					Assay Description Blockade of mouse HCN2 expressed in HEK293 cells at -120 f-current amplitude by patch-clamp electrophysiological assay				J Med Chem 53: 6773-7 (2010) Article DOI: 10.1021/jm1006758 BindingDB Entry DOI: 10.7270/Q2T43T9J
					More data for this Ligand-Target Pair
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (Homo sapiens (Human))	BDBM50326985 (3,3'-((2Z,2'Z)-4,4'-(3,4-dimethoxyphenethylazanedi...) Show SMILES COc1ccc(CCN(C\C=C/CN2C=Cc3cc(OC)c(OC)cc3CC2=O)C\C=C/CN2C=Cc3cc(OC)c(OC)cc3CC2=O)cc1OC |c:14,36| Show InChI InChI=1S/C42H49N3O8/c1-48-35-12-11-30(23-36(35)49-2)13-20-43(16-7-9-18-44-21-14-31-24-37(50-3)39(52-5)26-33(31)28-41(44)46)17-8-10-19-45-22-15-32-25-38(51-4)40(53-6)27-34(32)29-42(45)47/h7-12,14-15,21-27H,13,16-20,28-29H2,1-6H3/b9-7-,10-8-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	7.07E+4	n/a	n/a	n/a	n/a
Laboratory of Design, Synthesis, and Study of Biologically Active Heterocycles (HeteroBioLab) Curated by ChEMBL					Assay Description Blockade of human HCN4 expressed in HEK293 cells at -120 f-current amplitude by patch-clamp electrophysiological assay				J Med Chem 53: 6773-7 (2010) Article DOI: 10.1021/jm1006758 BindingDB Entry DOI: 10.7270/Q2T43T9J
					More data for this Ligand-Target Pair
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Mus musculus)	BDBM50326985 (3,3'-((2Z,2'Z)-4,4'-(3,4-dimethoxyphenethylazanedi...) Show SMILES COc1ccc(CCN(C\C=C/CN2C=Cc3cc(OC)c(OC)cc3CC2=O)C\C=C/CN2C=Cc3cc(OC)c(OC)cc3CC2=O)cc1OC |c:14,36| Show InChI InChI=1S/C42H49N3O8/c1-48-35-12-11-30(23-36(35)49-2)13-20-43(16-7-9-18-44-21-14-31-24-37(50-3)39(52-5)26-33(31)28-41(44)46)17-8-10-19-45-22-15-32-25-38(51-4)40(53-6)27-34(32)29-42(45)47/h7-12,14-15,21-27H,13,16-20,28-29H2,1-6H3/b9-7-,10-8-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.07E+5	n/a	n/a	n/a	n/a
Laboratory of Design, Synthesis, and Study of Biologically Active Heterocycles (HeteroBioLab) Curated by ChEMBL					Assay Description Blockade of mouse HCN1 expressed in HEK293 cells at -120 f-current amplitude by patch-clamp electrophysiological assay				J Med Chem 53: 6773-7 (2010) Article DOI: 10.1021/jm1006758 BindingDB Entry DOI: 10.7270/Q2T43T9J
					More data for this Ligand-Target Pair