BDBM50327068 1-{4-[Methyl(5-methyl-5H-pyrrolo[3,2-d]pyrimidin-4-yl)-amino]phenyl}-3-[3-(trifluoromethyl)phenyl]urea::CHEMBL1254095

SMILES: CN(c1ccc(NC(=O)Nc2cccc(c2)C(F)(F)F)cc1)c1ncnc2ccn(C)c12

InChI Key: InChIKey=MNSYGLMJOPPFTK-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50327068   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50327068 (1-{4-[Methyl(5-methyl-5H-pyrrolo[3,2-d]pyrimidin-4...) Show SMILES CN(c1ccc(NC(=O)Nc2cccc(c2)C(F)(F)F)cc1)c1ncnc2ccn(C)c12 Show InChI InChI=1S/C22H19F3N6O/c1-30-11-10-18-19(30)20(27-13-26-18)31(2)17-8-6-15(7-9-17)28-21(32)29-16-5-3-4-14(12-16)22(23,24)25/h3-13H,1-2H3,(H2,28,29,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd Curated by ChEMBL					Assay Description Inhibition of human VEGFR2				Bioorg Med Chem 18: 7260-73 (2010) Article DOI: 10.1016/j.bmc.2010.08.017 BindingDB Entry DOI: 10.7270/Q2NC61DC
					More data for this Ligand-Target Pair