BDBM50327080 1-{2-Chloro-4-[(5-methyl-5H-pyrrolo[3,2-d]pyrimidin-4-yl)oxy]phenyl}-3-[3-morpholin-4-yl-5-(trifluoromethyl)-phenyl]urea::CHEMBL1254927

SMILES: Cn1ccc2ncnc(Oc3ccc(NC(=O)Nc4cc(cc(c4)C(F)(F)F)N4CCOCC4)c(Cl)c3)c12

InChI Key: InChIKey=FABQZDSYMCCCAA-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50327080   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM50327080 (1-{2-Chloro-4-[(5-methyl-5H-pyrrolo[3,2-d]pyrimidi...) Show SMILES Cn1ccc2ncnc(Oc3ccc(NC(=O)Nc4cc(cc(c4)C(F)(F)F)N4CCOCC4)c(Cl)c3)c12 Show InChI InChI=1S/C25H22ClF3N6O3/c1-34-5-4-21-22(34)23(31-14-30-21)38-18-2-3-20(19(26)13-18)33-24(36)32-16-10-15(25(27,28)29)11-17(12-16)35-6-8-37-9-7-35/h2-5,10-14H,6-9H2,1H3,(H2,32,33,36)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd Curated by ChEMBL					Assay Description Inhibition of His-tagged human FGFR1 expressed in Sf9 cells				Bioorg Med Chem 18: 7150-63 (2010) Article DOI: 10.1016/j.bmc.2010.08.042 BindingDB Entry DOI: 10.7270/Q2HM58PN
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50327080 (1-{2-Chloro-4-[(5-methyl-5H-pyrrolo[3,2-d]pyrimidi...) Show SMILES Cn1ccc2ncnc(Oc3ccc(NC(=O)Nc4cc(cc(c4)C(F)(F)F)N4CCOCC4)c(Cl)c3)c12 Show InChI InChI=1S/C25H22ClF3N6O3/c1-34-5-4-21-22(34)23(31-14-30-21)38-18-2-3-20(19(26)13-18)33-24(36)32-16-10-15(25(27,28)29)11-17(12-16)35-6-8-37-9-7-35/h2-5,10-14H,6-9H2,1H3,(H2,32,33,36)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd Curated by ChEMBL					Assay Description Inhibition of His-tagged human VEGFR2 expressed in Sf9 cells				Bioorg Med Chem 18: 7150-63 (2010) Article DOI: 10.1016/j.bmc.2010.08.042 BindingDB Entry DOI: 10.7270/Q2HM58PN
					More data for this Ligand-Target Pair