BDBM50327298 4-(4-(1-amino-3-(4-(2-(2,6-dichloro-4-methylphenoxy)ethoxy)phenyl)propan-2-yl)-3-methylphenyl)pyridin-2-amine::CHEMBL1258394

SMILES: Cc1cc(Cl)c(OCCOc2ccc(CC(CN)c3ccc(cc3C)-c3ccnc(N)c3)cc2)c(Cl)c1

InChI Key: InChIKey=XHLCQIDTHMOIJG-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50327298   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Renin (Homo sapiens (Human))	BDBM50327298 (4-(4-(1-amino-3-(4-(2-(2,6-dichloro-4-methylphenox...) Show SMILES Cc1cc(Cl)c(OCCOc2ccc(CC(CN)c3ccc(cc3C)-c3ccnc(N)c3)cc2)c(Cl)c1 Show InChI InChI=1S/C30H31Cl2N3O2/c1-19-13-27(31)30(28(32)14-19)37-12-11-36-25-6-3-21(4-7-25)16-24(18-33)26-8-5-22(15-20(26)2)23-9-10-35-29(34)17-23/h3-10,13-15,17,24H,11-12,16,18,33H2,1-2H3,(H2,34,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	228	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Center for Therapeutic Research Curated by ChEMBL					Assay Description Inhibition of human recombinant renin in plasma				Bioorg Med Chem Lett 20: 5822-6 (2010) Article DOI: 10.1016/j.bmcl.2010.07.127 BindingDB Entry DOI: 10.7270/Q2ZP46BP
					More data for this Ligand-Target Pair
Renin (Homo sapiens (Human))	BDBM50327298 (4-(4-(1-amino-3-(4-(2-(2,6-dichloro-4-methylphenox...) Show SMILES Cc1cc(Cl)c(OCCOc2ccc(CC(CN)c3ccc(cc3C)-c3ccnc(N)c3)cc2)c(Cl)c1 Show InChI InChI=1S/C30H31Cl2N3O2/c1-19-13-27(31)30(28(32)14-19)37-12-11-36-25-6-3-21(4-7-25)16-24(18-33)26-8-5-22(15-20(26)2)23-9-10-35-29(34)17-23/h3-10,13-15,17,24H,11-12,16,18,33H2,1-2H3,(H2,34,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Center for Therapeutic Research Curated by ChEMBL					Assay Description Inhibition of human recombinant renin in phosphate buffer				Bioorg Med Chem Lett 20: 5822-6 (2010) Article DOI: 10.1016/j.bmcl.2010.07.127 BindingDB Entry DOI: 10.7270/Q2ZP46BP
					More data for this Ligand-Target Pair