BDBM50327489 8-(3-((2S,5S)-2,5-dimethylpyrrolidin-1-yl)propoxy)-3,4-dihydropyrazino[1,2-a]indol-1(2H)-one::CHEMBL1258309

SMILES: C[C@H]1CC[C@H](C)N1CCCOc1ccc2n3CCNC(=O)c3cc2c1

InChI Key: InChIKey=QPIPBVKEZITOKG-GJZGRUSLSA-N

Data: 1 KI  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50327489   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histamine H3 receptor (Homo sapiens (Human))	BDBM50327489 (8-(3-((2S,5S)-2,5-dimethylpyrrolidin-1-yl)propoxy)...) Show SMILES C[C@H]1CC[C@H](C)N1CCCOc1ccc2n3CCNC(=O)c3cc2c1 |r| Show InChI InChI=1S/C20H27N3O2/c1-14-4-5-15(2)22(14)9-3-11-25-17-6-7-18-16(12-17)13-19-20(24)21-8-10-23(18)19/h6-7,12-15H,3-5,8-11H2,1-2H3,(H,21,24)/t14-,15-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	11	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
F Hoffmann-La Roche Ltd Curated by ChEMBL					Assay Description Displacement of [3H]-RAMH from human histamine H3 receptor				Bioorg Med Chem Lett 20: 5713-7 (2010) Article DOI: 10.1016/j.bmcl.2010.08.009 BindingDB Entry DOI: 10.7270/Q2571C7N
					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50327489 (8-(3-((2S,5S)-2,5-dimethylpyrrolidin-1-yl)propoxy)...) Show SMILES C[C@H]1CC[C@H](C)N1CCCOc1ccc2n3CCNC(=O)c3cc2c1 |r| Show InChI InChI=1S/C20H27N3O2/c1-14-4-5-15(2)22(14)9-3-11-25-17-6-7-18-16(12-17)13-19-20(24)21-8-10-23(18)19/h6-7,12-15H,3-5,8-11H2,1-2H3,(H,21,24)/t14-,15-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	24	n/a	n/a	n/a	n/a
F Hoffmann-La Roche Ltd Curated by ChEMBL					Assay Description Inverse agonist activity at human recombinant histamine H3 receptor assessed as effect on [35S]GTPgammaS binding				Bioorg Med Chem Lett 20: 5713-7 (2010) Article DOI: 10.1016/j.bmcl.2010.08.009 BindingDB Entry DOI: 10.7270/Q2571C7N
					More data for this Ligand-Target Pair