Found 4 hits for monomerid = 50327583 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human)) | BDBM50327583
(6-(4-(4-(6,7-difluoronaphthalen-1-yl)piperazin-1-y...)Show SMILES Fc1cc2cccc(N3CCN(CCCCOc4ccc5CNC(=O)c5c4)CC3)c2cc1F Show InChI InChI=1S/C26H27F2N3O2/c27-23-14-18-4-3-5-25(21(18)16-24(23)28)31-11-9-30(10-12-31)8-1-2-13-33-20-7-6-19-17-29-26(32)22(19)15-20/h3-7,14-16H,1-2,8-13,17H2,(H,29,32) | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Displacement of [3H]-8-OH-DPAT from human 5HT1A receptor expressed in HeLa cells |
Bioorg Med Chem Lett 20: 5666-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.08.023 BindingDB Entry DOI: 10.7270/Q2HH6K9S |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 2A
(Homo sapiens (Human)) | BDBM50327583
(6-(4-(4-(6,7-difluoronaphthalen-1-yl)piperazin-1-y...)Show SMILES Fc1cc2cccc(N3CCN(CCCCOc4ccc5CNC(=O)c5c4)CC3)c2cc1F Show InChI InChI=1S/C26H27F2N3O2/c27-23-14-18-4-3-5-25(21(18)16-24(23)28)31-11-9-30(10-12-31)8-1-2-13-33-20-7-6-19-17-29-26(32)22(19)15-20/h3-7,14-16H,1-2,8-13,17H2,(H,29,32) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 7.91 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Binding affinity to human 5HT2A receptor |
Bioorg Med Chem Lett 20: 5666-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.08.023 BindingDB Entry DOI: 10.7270/Q2HH6K9S |
More data for this Ligand-Target Pair | |
D(2) dopamine receptor
(Homo sapiens (Human)) | BDBM50327583
(6-(4-(4-(6,7-difluoronaphthalen-1-yl)piperazin-1-y...)Show SMILES Fc1cc2cccc(N3CCN(CCCCOc4ccc5CNC(=O)c5c4)CC3)c2cc1F Show InChI InChI=1S/C26H27F2N3O2/c27-23-14-18-4-3-5-25(21(18)16-24(23)28)31-11-9-30(10-12-31)8-1-2-13-33-20-7-6-19-17-29-26(32)22(19)15-20/h3-7,14-16H,1-2,8-13,17H2,(H,29,32) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 8.23 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Displacement of [3H]-Spiperone from human dopamine D2L receptor expressed in CHO cells |
Bioorg Med Chem Lett 20: 5666-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.08.023 BindingDB Entry DOI: 10.7270/Q2HH6K9S |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50327583
(6-(4-(4-(6,7-difluoronaphthalen-1-yl)piperazin-1-y...)Show SMILES Fc1cc2cccc(N3CCN(CCCCOc4ccc5CNC(=O)c5c4)CC3)c2cc1F Show InChI InChI=1S/C26H27F2N3O2/c27-23-14-18-4-3-5-25(21(18)16-24(23)28)31-11-9-30(10-12-31)8-1-2-13-33-20-7-6-19-17-29-26(32)22(19)15-20/h3-7,14-16H,1-2,8-13,17H2,(H,29,32) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1.86E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Displacement of [3H]dofetilide from human ERG |
Bioorg Med Chem Lett 20: 5666-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.08.023 BindingDB Entry DOI: 10.7270/Q2HH6K9S |
More data for this Ligand-Target Pair | |