BDBM50327989 CHEMBL1257999::N-(2-((4-cyanophenyl)((1-methyl-1H-imidazol-5-yl)methyl)amino)ethyl)-N-((2,4-dimethylthiazol-5-yl)methyl)-1-methyl-1H-imidazole-4-sulfonamide

SMILES: Cc1nc(C)c(CN(CCN(Cc2cncn2C)c2ccc(cc2)C#N)S(=O)(=O)c2cn(C)cn2)s1

InChI Key: InChIKey=LKYOQEIVVIUESZ-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50327989   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Geranylgeranyl transferase type 1 (Mus musculus)	BDBM50327989 (CHEMBL1257999 | N-(2-((4-cyanophenyl)((1-methyl-1H...) Show SMILES Cc1nc(C)c(CN(CCN(Cc2cncn2C)c2ccc(cc2)C#N)S(=O)(=O)c2cn(C)cn2)s1 Show InChI InChI=1S/C24H28N8O2S2/c1-18-23(35-19(2)28-18)14-32(36(33,34)24-15-29(3)17-27-24)10-9-31(13-22-12-26-16-30(22)4)21-7-5-20(11-25)6-8-21/h5-8,12,15-17H,9-10,13-14H2,1-4H3	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Yale University Curated by ChEMBL					Assay Description Inhibition of Rap1A geranylgeranylation expressed in mouse NIH3T3 cells				J Med Chem 53: 6867-88 (2010) Article DOI: 10.1021/jm1001748 BindingDB Entry DOI: 10.7270/Q26110JC
					More data for this Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT) (Homo sapiens (Human))	BDBM50327989 (CHEMBL1257999 | N-(2-((4-cyanophenyl)((1-methyl-1H...) Show SMILES Cc1nc(C)c(CN(CCN(Cc2cncn2C)c2ccc(cc2)C#N)S(=O)(=O)c2cn(C)cn2)s1 Show InChI InChI=1S/C24H28N8O2S2/c1-18-23(35-19(2)28-18)14-32(36(33,34)24-15-29(3)17-27-24)10-9-31(13-22-12-26-16-30(22)4)21-7-5-20(11-25)6-8-21/h5-8,12,15-17H,9-10,13-14H2,1-4H3	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Yale University Curated by ChEMBL					Assay Description Inhibition of human geranylgeranyltransferase-1 assessed as incorporation of [3H]GGPP into H-Ras-CVLL				J Med Chem 53: 6867-88 (2010) Article DOI: 10.1021/jm1001748 BindingDB Entry DOI: 10.7270/Q26110JC
					More data for this Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit (Mus musculus)	BDBM50327989 (CHEMBL1257999 | N-(2-((4-cyanophenyl)((1-methyl-1H...) Show SMILES Cc1nc(C)c(CN(CCN(Cc2cncn2C)c2ccc(cc2)C#N)S(=O)(=O)c2cn(C)cn2)s1 Show InChI InChI=1S/C24H28N8O2S2/c1-18-23(35-19(2)28-18)14-32(36(33,34)24-15-29(3)17-27-24)10-9-31(13-22-12-26-16-30(22)4)21-7-5-20(11-25)6-8-21/h5-8,12,15-17H,9-10,13-14H2,1-4H3	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Yale University Curated by ChEMBL					Assay Description Inhibition of H-Ras farnesylation expressed in mouse NIH3T3 cells				J Med Chem 53: 6867-88 (2010) Article DOI: 10.1021/jm1001748 BindingDB Entry DOI: 10.7270/Q26110JC
					More data for this Ligand-Target Pair
Protein Farnesyltransferase (PFT) (Homo sapiens (Human))	BDBM50327989 (CHEMBL1257999 | N-(2-((4-cyanophenyl)((1-methyl-1H...) Show SMILES Cc1nc(C)c(CN(CCN(Cc2cncn2C)c2ccc(cc2)C#N)S(=O)(=O)c2cn(C)cn2)s1 Show InChI InChI=1S/C24H28N8O2S2/c1-18-23(35-19(2)28-18)14-32(36(33,34)24-15-29(3)17-27-24)10-9-31(13-22-12-26-16-30(22)4)21-7-5-20(11-25)6-8-21/h5-8,12,15-17H,9-10,13-14H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Yale University Curated by ChEMBL					Assay Description Inhibition of human farnesyltransferase assessed as incorporation of [3H]FPP into H-Ras-CVLS				J Med Chem 53: 6867-88 (2010) Article DOI: 10.1021/jm1001748 BindingDB Entry DOI: 10.7270/Q26110JC
					More data for this Ligand-Target Pair