BDBM50328093 2,2-Dimethyl-5-morpholin-4-yl-N-(pyridin-3-ylmethyl)-1,2,3,4-tetrahydropyrimido[4',5':4,5]thieno[2,3-c]isoquinolin-8-amine::CHEMBL1257536

SMILES: CC1(C)CCc2c(C1)c1c(nc2N2CCOCC2)sc2c(NCc3cccnc3)ncnc12

InChI Key: InChIKey=IKADFHCDTYOPKD-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50328093   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50328093 (2,2-Dimethyl-5-morpholin-4-yl-N-(pyridin-3-ylmethy...) Show SMILES CC1(C)CCc2c(C1)c1c(nc2N2CCOCC2)sc2c(NCc3cccnc3)ncnc12 Show InChI InChI=1S/C25H28N6OS/c1-25(2)6-5-17-18(12-25)19-20-21(33-24(19)30-23(17)31-8-10-32-11-9-31)22(29-15-28-20)27-14-16-4-3-7-26-13-16/h3-4,7,13,15H,5-6,8-12,14H2,1-2H3,(H,27,28,29)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.60	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Inhibition of PDE4B1 expressed in yeast				J Med Chem 53: 6912-22 (2010) Article DOI: 10.1021/jm100524j BindingDB Entry DOI: 10.7270/Q2J966K2
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50328093 (2,2-Dimethyl-5-morpholin-4-yl-N-(pyridin-3-ylmethy...) Show SMILES CC1(C)CCc2c(C1)c1c(nc2N2CCOCC2)sc2c(NCc3cccnc3)ncnc12 Show InChI InChI=1S/C25H28N6OS/c1-25(2)6-5-17-18(12-25)19-20-21(33-24(19)30-23(17)31-8-10-32-11-9-31)22(29-15-28-20)27-14-16-4-3-7-26-13-16/h3-4,7,13,15H,5-6,8-12,14H2,1-2H3,(H,27,28,29)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Inhibition of PDE4D3 expressed in yeast				J Med Chem 53: 6912-22 (2010) Article DOI: 10.1021/jm100524j BindingDB Entry DOI: 10.7270/Q2J966K2
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A (Homo sapiens (Human))	BDBM50328093 (2,2-Dimethyl-5-morpholin-4-yl-N-(pyridin-3-ylmethy...) Show SMILES CC1(C)CCc2c(C1)c1c(nc2N2CCOCC2)sc2c(NCc3cccnc3)ncnc12 Show InChI InChI=1S/C25H28N6OS/c1-25(2)6-5-17-18(12-25)19-20-21(33-24(19)30-23(17)31-8-10-32-11-9-31)22(29-15-28-20)27-14-16-4-3-7-26-13-16/h3-4,7,13,15H,5-6,8-12,14H2,1-2H3,(H,27,28,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.5	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Inhibition of PDE4A4 expressed in yeast				J Med Chem 53: 6912-22 (2010) Article DOI: 10.1021/jm100524j BindingDB Entry DOI: 10.7270/Q2J966K2
					More data for this Ligand-Target Pair