BDBM50328095 CHEMBL1258806::N5,2,2-Trimethyl-N8-(2-morpholin-4-ylethyl)-1,2,3,4-tetrahydropyrimido[4',5':4,5]thieno[2,3-c]isoquinolin-5,8-diamine

SMILES: CNc1nc2sc3c(NCCN4CCOCC4)ncnc3c2c2CC(C)(C)CCc12

InChI Key: InChIKey=CKDYACSCRUTGHR-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50328095   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50328095 (CHEMBL1258806 | N5,2,2-Trimethyl-N8-(2-morpholin-4...) Show SMILES CNc1nc2sc3c(NCCN4CCOCC4)ncnc3c2c2CC(C)(C)CCc12 Show InChI InChI=1S/C22H30N6OS/c1-22(2)5-4-14-15(12-22)16-17-18(30-21(16)27-19(14)23-3)20(26-13-25-17)24-6-7-28-8-10-29-11-9-28/h13H,4-12H2,1-3H3,(H,23,27)(H,24,25,26)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.20	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Inhibition of PDE4D3 expressed in yeast				J Med Chem 53: 6912-22 (2010) Article DOI: 10.1021/jm100524j BindingDB Entry DOI: 10.7270/Q2J966K2
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A (Homo sapiens (Human))	BDBM50328095 (CHEMBL1258806 | N5,2,2-Trimethyl-N8-(2-morpholin-4...) Show SMILES CNc1nc2sc3c(NCCN4CCOCC4)ncnc3c2c2CC(C)(C)CCc12 Show InChI InChI=1S/C22H30N6OS/c1-22(2)5-4-14-15(12-22)16-17-18(30-21(16)27-19(14)23-3)20(26-13-25-17)24-6-7-28-8-10-29-11-9-28/h13H,4-12H2,1-3H3,(H,23,27)(H,24,25,26)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Inhibition of PDE4A4 expressed in yeast				J Med Chem 53: 6912-22 (2010) Article DOI: 10.1021/jm100524j BindingDB Entry DOI: 10.7270/Q2J966K2
					More data for this Ligand-Target Pair
3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50328095 (CHEMBL1258806 | N5,2,2-Trimethyl-N8-(2-morpholin-4...) Show SMILES CNc1nc2sc3c(NCCN4CCOCC4)ncnc3c2c2CC(C)(C)CCc12 Show InChI InChI=1S/C22H30N6OS/c1-22(2)5-4-14-15(12-22)16-17-18(30-21(16)27-19(14)23-3)20(26-13-25-17)24-6-7-28-8-10-29-11-9-28/h13H,4-12H2,1-3H3,(H,23,27)(H,24,25,26)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.90	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Inhibition of PDE4B1 expressed in yeast				J Med Chem 53: 6912-22 (2010) Article DOI: 10.1021/jm100524j BindingDB Entry DOI: 10.7270/Q2J966K2
					More data for this Ligand-Target Pair