BDBM50328108 CHEMBL1258690::N5,2,2-trimethyl-N8-(2-morpholin-4-ylethyl)-1,4-dihydro-2Hpyrano[4'',3'':4',5']pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-5,8-diamine

SMILES: CNc1nc2sc3c(NCCN4CCOCC4)ncnc3c2c2CC(C)(C)OCc12

InChI Key: InChIKey=XFOVLZCCWBZMHW-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50328108   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50328108 (CHEMBL1258690 | N5,2,2-trimethyl-N8-(2-morpholin-4...) Show SMILES CNc1nc2sc3c(NCCN4CCOCC4)ncnc3c2c2CC(C)(C)OCc12 Show InChI InChI=1S/C21H28N6O2S/c1-21(2)10-13-14(11-29-21)18(22-3)26-20-15(13)16-17(30-20)19(25-12-24-16)23-4-5-27-6-8-28-9-7-27/h12H,4-11H2,1-3H3,(H,22,26)(H,23,24,25)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	51	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Inhibition of PDE4B1 expressed in yeast				J Med Chem 53: 6912-22 (2010) Article DOI: 10.1021/jm100524j BindingDB Entry DOI: 10.7270/Q2J966K2
					More data for this Ligand-Target Pair