BDBM50328117 2,2-Dimethyl-5-(4-methylpiperazin-1-yl)-N-(2-morpholin-4-ylethyl)-1,4-dihydro-2H-pyrano[4'',3'':4',5']pyrido[3',2':4,5]thieno-[3,2-d]pyrimidin-8-amine::CHEMBL1258579

SMILES: CN1CCN(CC1)c1nc2sc3c(NCCN4CCOCC4)ncnc3c2c2CC(C)(C)OCc12

InChI Key: InChIKey=NOQMQFMWJGFBMW-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50328117   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50328117 (2,2-Dimethyl-5-(4-methylpiperazin-1-yl)-N-(2-morph...) Show SMILES CN1CCN(CC1)c1nc2sc3c(NCCN4CCOCC4)ncnc3c2c2CC(C)(C)OCc12 Show InChI InChI=1S/C25H35N7O2S/c1-25(2)14-17-18(15-34-25)23(32-8-6-30(3)7-9-32)29-24-19(17)20-21(35-24)22(28-16-27-20)26-4-5-31-10-12-33-13-11-31/h16H,4-15H2,1-3H3,(H,26,27,28)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Inhibition of PDE4B1 expressed in yeast				J Med Chem 53: 6912-22 (2010) Article DOI: 10.1021/jm100524j BindingDB Entry DOI: 10.7270/Q2J966K2
					More data for this Ligand-Target Pair