BDBM50328352 CHEMBL1256009::diethyl 7-(biphenyl-4-yl)-2-morpholino-4-phenylpyrrolo[1,2-b]pyridazine-5,6-dicarboxylate

SMILES: CCOC(=O)c1c(C(=O)OCC)c2c(cc(nn2c1-c1ccc(cc1)-c1ccccc1)N1CCOCC1)-c1ccccc1

InChI Key: InChIKey=BFFOKCULBQPSHH-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50328352   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Diacylglycerol O-acyltransferase 1 (DGAT1) (Homo sapiens (Human))	BDBM50328352 (CHEMBL1256009 | diethyl 7-(biphenyl-4-yl)-2-morpho...) Show SMILES CCOC(=O)c1c(C(=O)OCC)c2c(cc(nn2c1-c1ccc(cc1)-c1ccccc1)N1CCOCC1)-c1ccccc1 Show InChI InChI=1S/C35H33N3O5/c1-3-42-34(39)30-31(35(40)43-4-2)33-28(26-13-9-6-10-14-26)23-29(37-19-21-41-22-20-37)36-38(33)32(30)27-17-15-25(16-18-27)24-11-7-5-8-12-24/h5-18,23H,3-4,19-22H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	250	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs				Bioorg Med Chem Lett 20: 6030-3 (2010) Article DOI: 10.1016/j.bmcl.2010.08.066 BindingDB Entry DOI: 10.7270/Q2RV0NX1
					More data for this Ligand-Target Pair
Sterol O-acyltransferase 1 (Homo sapiens (Human))	BDBM50328352 (CHEMBL1256009 | diethyl 7-(biphenyl-4-yl)-2-morpho...) Show SMILES CCOC(=O)c1c(C(=O)OCC)c2c(cc(nn2c1-c1ccc(cc1)-c1ccccc1)N1CCOCC1)-c1ccccc1 Show InChI InChI=1S/C35H33N3O5/c1-3-42-34(39)30-31(35(40)43-4-2)33-28(26-13-9-6-10-14-26)23-29(37-19-21-41-22-20-37)36-38(33)32(30)27-17-15-25(16-18-27)24-11-7-5-8-12-24/h5-18,23H,3-4,19-22H2,1-2H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	<300	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human full-length flag-tagged ACAT1 expressed in baculovirus infected insect cells after 10 mins				Bioorg Med Chem Lett 20: 6030-3 (2010) Article DOI: 10.1016/j.bmcl.2010.08.066 BindingDB Entry DOI: 10.7270/Q2RV0NX1
					More data for this Ligand-Target Pair