BDBM50328428 2-methoxy-N-(3-(8-(4-methoxyphenylamino)imidazo[1,2-a]pyrazin-6-yl)phenyl)acetamide::CHEMBL1258151

SMILES: COCC(=O)Nc1cccc(c1)-c1cn2ccnc2c(Nc2ccc(OC)cc2)n1

InChI Key: InChIKey=UAVIDYPAYSLILU-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50328428   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Aurora kinase A (Homo sapiens (Human))	BDBM50328428 (2-methoxy-N-(3-(8-(4-methoxyphenylamino)imidazo[1,...) Show SMILES COCC(=O)Nc1cccc(c1)-c1cn2ccnc2c(Nc2ccc(OC)cc2)n1 Show InChI InChI=1S/C22H21N5O3/c1-29-14-20(28)24-17-5-3-4-15(12-17)19-13-27-11-10-23-22(27)21(26-19)25-16-6-8-18(30-2)9-7-16/h3-13H,14H2,1-2H3,(H,24,28)(H,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.31E+3	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of human aurora A				Bioorg Med Chem Lett 20: 5988-93 (2010) Article DOI: 10.1016/j.bmcl.2010.08.091 BindingDB Entry DOI: 10.7270/Q2H995D7
					More data for this Ligand-Target Pair