BDBM50328639 (3-Chloro-4-fluoro-phenyl)-(4-fluoro-4-{[(5-methyl-pyridin-2-ylmethyl)-amino]-methyl}-piperidin-1-yl)-methanone::(3-chloro-4-fluorophenyl)(4-fluoro-4-(((5-methylpyridin-2-yl)methylamino)methyl)piperidin-1-yl)methanone::Befiradol::CHEMBL45305::US10562853, Compound Befiradol
SMILES: Cc1ccc(CNCC2(F)CCN(CC2)C(=O)c2ccc(F)c(Cl)c2)nc1
InChI Key: InChIKey=PKZXLMVXBZICTF-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM50328639 ((3-Chloro-4-fluoro-phenyl)-(4-fluoro-4-{[(5-methyl...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | US Patent | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NEUROLIXIS; UNIVERSITE JAGELLONE US Patent | Assay Description 5-HT1A: Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human 5-HT1A receptor. All assays were carrie... | US Patent US10562853 (2020) BindingDB Entry DOI: 10.7270/Q29Z979D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat)) | BDBM50328639 ((3-Chloro-4-fluoro-phenyl)-(4-fluoro-4-{[(5-methyl...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 0.851 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pierre Fabre Research Center Curated by ChEMBL | Assay Description Binding affinity towards 5-hydroxytryptamine 1A receptor in rat cortex using [3H]8-OH-DPAT as a radioligand | J Med Chem 42: 1648-60 (1999) Article DOI: 10.1021/jm9806906 BindingDB Entry DOI: 10.7270/Q2MS3WHR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat)) | BDBM50328639 ((3-Chloro-4-fluoro-phenyl)-(4-fluoro-4-{[(5-methyl...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 0.851 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pierre Fabre Research Center Curated by ChEMBL | Assay Description Binding affinity to 5HT1A receptor in rat cortex membrane | J Med Chem 50: 5024-33 (2007) Article DOI: 10.1021/jm070714l BindingDB Entry DOI: 10.7270/Q2HH6NTB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-1A adrenergic receptor (Homo sapiens (Human)) | BDBM50328639 ((3-Chloro-4-fluoro-phenyl)-(4-fluoro-4-{[(5-methyl...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | US Patent | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NEUROLIXIS; UNIVERSITE JAGELLONE US Patent | Assay Description Alpha1-adrenergic Receptor: Radioligand binding was performed using tissue (rat cortex). All assays were carried out in duplicates. 50 μL workin... | US Patent US10562853 (2020) BindingDB Entry DOI: 10.7270/Q29Z979D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Homo sapiens (Human)) | BDBM50328639 ((3-Chloro-4-fluoro-phenyl)-(4-fluoro-4-{[(5-methyl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | US Patent | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NEUROLIXIS; UNIVERSITE JAGELLONE US Patent | Assay Description D2 Dopamine Receptor:Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human D2 receptor. All assays we... | US Patent US10562853 (2020) BindingDB Entry DOI: 10.7270/Q29Z979D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(3) dopamine receptor (Homo sapiens (Human)) | BDBM50328639 ((3-Chloro-4-fluoro-phenyl)-(4-fluoro-4-{[(5-methyl...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Friedrich Alexander University Curated by ChEMBL | Assay Description Displacement of [3H]Spiperone from human dopamine D3 receptor | J Med Chem 53: 7167-79 (2010) Article DOI: 10.1021/jm100835q BindingDB Entry DOI: 10.7270/Q2GB249V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Homo sapiens (Human)) | BDBM50328639 ((3-Chloro-4-fluoro-phenyl)-(4-fluoro-4-{[(5-methyl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 1.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Friedrich Alexander University Curated by ChEMBL | Assay Description Displacement of [3H]Spiperone from human dopamine D2 long receptor | J Med Chem 53: 7167-79 (2010) Article DOI: 10.1021/jm100835q BindingDB Entry DOI: 10.7270/Q2GB249V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-HT2 (PIG) | BDBM50328639 ((3-Chloro-4-fluoro-phenyl)-(4-fluoro-4-{[(5-methyl...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 2.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Friedrich Alexander University Curated by ChEMBL | Assay Description Displacement of [3H]Ketanserin from 5-HT2 receptor in pig cortex membranes | J Med Chem 53: 7167-79 (2010) Article DOI: 10.1021/jm100835q BindingDB Entry DOI: 10.7270/Q2GB249V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dopamine D1 receptor (Sus scrofa) | BDBM50328639 ((3-Chloro-4-fluoro-phenyl)-(4-fluoro-4-{[(5-methyl...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 2.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Friedrich Alexander University Curated by ChEMBL | Assay Description Displacement of [3H]SCH23390 from dopamine D1 receptor in pig cortex membranes | J Med Chem 53: 7167-79 (2010) Article DOI: 10.1021/jm100835q BindingDB Entry DOI: 10.7270/Q2GB249V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Homo sapiens (Human)) | BDBM50328639 ((3-Chloro-4-fluoro-phenyl)-(4-fluoro-4-{[(5-methyl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 4.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Friedrich Alexander University Curated by ChEMBL | Assay Description Displacement of [3H]Spiperone from human dopamine D2 short receptor | J Med Chem 53: 7167-79 (2010) Article DOI: 10.1021/jm100835q BindingDB Entry DOI: 10.7270/Q2GB249V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM50328639 ((3-Chloro-4-fluoro-phenyl)-(4-fluoro-4-{[(5-methyl...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 26 | n/a | n/a | n/a | n/a |
Pierre Fabre Research Center Curated by ChEMBL | Assay Description In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor | J Med Chem 42: 1648-60 (1999) Article DOI: 10.1021/jm9806906 BindingDB Entry DOI: 10.7270/Q2MS3WHR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM50328639 ((3-Chloro-4-fluoro-phenyl)-(4-fluoro-4-{[(5-methyl...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 23 | n/a | n/a | n/a | n/a |
Pierre Fabre Research Center Curated by ChEMBL | Assay Description Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding | J Med Chem 50: 5024-33 (2007) Article DOI: 10.1021/jm070714l BindingDB Entry DOI: 10.7270/Q2HH6NTB | |||||||||||
More data for this Ligand-Target Pair |