BDBM50328808 CHEMBL1270060::rac-1,2,5-trimethyl-4-(naphthalen-2-ylethynyl)piperidin-4-ol
SMILES: CC1CC(O)(C#Cc2ccc3ccccc3c2)C(C)CN1C
InChI Key: InChIKey=NBAJUKAFIJTFNK-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Histamine H3 receptor (Homo sapiens (Human)) | BDBM50328808 (CHEMBL1270060 | rac-1,2,5-trimethyl-4-(naphthalen-...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 84 | n/a | n/a | n/a | n/a | n/a | n/a |
Athersys Inc. Curated by ChEMBL | Assay Description Antagonist activity against human histamine H3 receptor expressed in human HT1080 cells assessed as inhibition of (R)-alpha-methylhistamine-induced i... | Bioorg Med Chem Lett 20: 6246-9 (2010) Article DOI: 10.1016/j.bmcl.2010.08.099 BindingDB Entry DOI: 10.7270/Q2DF6RGG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H3 receptor (Mus musculus) | BDBM50328808 (CHEMBL1270060 | rac-1,2,5-trimethyl-4-(naphthalen-...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 810 | n/a | n/a | n/a | n/a | n/a | n/a |
Athersys Inc. Curated by ChEMBL | Assay Description Antagonist activity against mouse histamine H3 receptor expressed in human HT1080 cells assessed as inhibition of (R)-alpha-methylhistamine-induced i... | Bioorg Med Chem Lett 20: 6246-9 (2010) Article DOI: 10.1016/j.bmcl.2010.08.099 BindingDB Entry DOI: 10.7270/Q2DF6RGG | |||||||||||
More data for this Ligand-Target Pair |