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BDBM50329389 4'-(5-(1-(4-tert-butylphenyl)-1-hydroxy-3-morpholinopropyl)-2-chlorophenethoxy)biphenyl-4-carboxylic acid::CHEMBL1269506

SMILES: CC(C)(C)c1ccc(cc1)C(O)(CCN1CCOCC1)c1ccc(Cl)c(CCOc2ccc(cc2)-c2ccc(cc2)C(O)=O)c1

InChI Key: InChIKey=DKTLTMZXRUAZAB-UHFFFAOYSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50329389   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM50329389
PNG
(4'-(5-(1-(4-tert-butylphenyl)-1-hydroxy-3-morpholi...)
Show SMILES CC(C)(C)c1ccc(cc1)C(O)(CCN1CCOCC1)c1ccc(Cl)c(CCOc2ccc(cc2)-c2ccc(cc2)C(O)=O)c1
Show InChI InChI=1S/C38H42ClNO5/c1-37(2,3)31-10-12-32(13-11-31)38(43,19-20-40-21-24-44-25-22-40)33-14-17-35(39)30(26-33)18-23-45-34-15-8-28(9-16-34)27-4-6-29(7-5-27)36(41)42/h4-17,26,43H,18-25H2,1-3H3,(H,41,42)
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

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Similars
Article
PubMed
 110n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Bcl-2 by fluorescence polarization assay

Bioorg Med Chem Lett 20: 6587-91 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.033
BindingDB Entry DOI: 10.7270/Q2J103C3
More data for this
Ligand-Target Pair