BDBM50329390 4'-(5-(1-(4-tert-butylphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propyl)-2-chlorophenethoxy)biphenyl-4-carboxylic acid::CHEMBL1269507

SMILES: CC(C)(C)c1ccc(cc1)C(O)(CCN1CCCC1)c1ccc(Cl)c(CCOc2ccc(cc2)-c2ccc(cc2)C(O)=O)c1

InChI Key: InChIKey=SKKNHOXGOILCBV-UHFFFAOYSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50329390   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM50329390 (4'-(5-(1-(4-tert-butylphenyl)-1-hydroxy-3-(pyrroli...) Show SMILES CC(C)(C)c1ccc(cc1)C(O)(CCN1CCCC1)c1ccc(Cl)c(CCOc2ccc(cc2)-c2ccc(cc2)C(O)=O)c1 Show InChI InChI=1S/C38H42ClNO4/c1-37(2,3)31-12-14-32(15-13-31)38(43,21-24-40-22-4-5-23-40)33-16-19-35(39)30(26-33)20-25-44-34-17-10-28(11-18-34)27-6-8-29(9-7-27)36(41)42/h6-19,26,43H,4-5,20-25H2,1-3H3,(H,41,42)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of Bcl-2 by fluorescence polarization assay				Bioorg Med Chem Lett 20: 6587-91 (2010) Article DOI: 10.1016/j.bmcl.2010.09.033 BindingDB Entry DOI: 10.7270/Q2J103C3
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