BDBM50329894 2-chloro-N-(6-(5-fluoro-4-hydroxy-6-methylpyrimidin-2-yl)pyridin-3-yl)acetamide::CHEMBL1269016

SMILES: Cc1nc([nH]c(=O)c1F)-c1ccc(NC(=O)CCl)cn1

InChI Key: InChIKey=UXNNZCZIBVBREP-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50329894   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Hypoxia-inducible factor 1-alpha (Homo sapiens (Human))	BDBM50329894 (2-chloro-N-(6-(5-fluoro-4-hydroxy-6-methylpyrimidi...) Show SMILES Cc1nc([nH]c(=O)c1F)-c1ccc(NC(=O)CCl)cn1 Show InChI InChI=1S/C12H10ClFN4O2/c1-6-10(14)12(20)18-11(16-6)8-3-2-7(5-15-8)17-9(19)4-13/h2-3,5H,4H2,1H3,(H,17,19)(H,16,18,20)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Piramal Life Sciences Curated by ChEMBL					Assay Description Inhibition of HIF1alpha in human U251 cells under hypoxic condition by luciferase reporter gene assay				Bioorg Med Chem Lett 20: 6426-9 (2010) Article DOI: 10.1016/j.bmcl.2010.09.083 BindingDB Entry DOI: 10.7270/Q2HX1CXM
					More data for this Ligand-Target Pair
Hypoxia-inducible factor 1-alpha (Homo sapiens (Human))	BDBM50329894 (2-chloro-N-(6-(5-fluoro-4-hydroxy-6-methylpyrimidi...) Show SMILES Cc1nc([nH]c(=O)c1F)-c1ccc(NC(=O)CCl)cn1 Show InChI InChI=1S/C12H10ClFN4O2/c1-6-10(14)12(20)18-11(16-6)8-3-2-7(5-15-8)17-9(19)4-13/h2-3,5H,4H2,1H3,(H,17,19)(H,16,18,20)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Piramal Life Sciences Curated by ChEMBL					Assay Description Inhibition of HIF1alpha in human U251 cells under normoxic condition by luciferase reporter gene assay				Bioorg Med Chem Lett 20: 6426-9 (2010) Article DOI: 10.1016/j.bmcl.2010.09.083 BindingDB Entry DOI: 10.7270/Q2HX1CXM
					More data for this Ligand-Target Pair