BDBM50329912 6-(4-ethoxy-6-(trifluoromethyl)pyrimidin-2-yl)pyridin-3-amine::CHEMBL1269486

SMILES: CCOc1cc(nc(n1)-c1ccc(N)cn1)C(F)(F)F

InChI Key: InChIKey=ZRCWDDPTQHZGHR-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50329912   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Hypoxia-inducible factor 1-alpha (Homo sapiens (Human))	BDBM50329912 (6-(4-ethoxy-6-(trifluoromethyl)pyrimidin-2-yl)pyri...) Show SMILES CCOc1cc(nc(n1)-c1ccc(N)cn1)C(F)(F)F Show InChI InChI=1S/C12H11F3N4O/c1-2-20-10-5-9(12(13,14)15)18-11(19-10)8-4-3-7(16)6-17-8/h3-6H,2,16H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Piramal Life Sciences Curated by ChEMBL					Assay Description Inhibition of HIF1alpha in human U251 cells under hypoxic condition by luciferase reporter gene assay				Bioorg Med Chem Lett 20: 6426-9 (2010) Article DOI: 10.1016/j.bmcl.2010.09.083 BindingDB Entry DOI: 10.7270/Q2HX1CXM
					More data for this Ligand-Target Pair