null

SMILES: CC(C)c1[nH]nc(Br)c1-c1ccnc(NC2CCN(C)CC2)n1

InChI Key: InChIKey=UONTVBODKZAAKG-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50330265   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 (Homo sapiens (Human))	BDBM50330265 (CHEMBL1271563 | [4-(5-Bromo-3-isopropyl-1H-pyrazol...) Show SMILES CC(C)c1[nH]nc(Br)c1-c1ccnc(NC2CCN(C)CC2)n1 Show InChI InChI=1S/C16H23BrN6/c1-10(2)14-13(15(17)22-21-14)12-4-7-18-16(20-12)19-11-5-8-23(3)9-6-11/h4,7,10-11H,5-6,8-9H2,1-3H3,(H,21,22)(H,18,19,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	76	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for Biomedical Research Curated by ChEMBL					Assay Description Inhibition of human CDK4/cyclin D1 expressed in baculovirus infected Sf21 cells after 60 mins by TR-FRET assay				J Med Chem 53: 7938-57 (2010) Article DOI: 10.1021/jm100571n BindingDB Entry DOI: 10.7270/Q2T72HQV
					More data for this Ligand-Target Pair
Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1 (Homo sapiens (Human))	BDBM50330265 (CHEMBL1271563 | [4-(5-Bromo-3-isopropyl-1H-pyrazol...) Show SMILES CC(C)c1[nH]nc(Br)c1-c1ccnc(NC2CCN(C)CC2)n1 Show InChI InChI=1S/C16H23BrN6/c1-10(2)14-13(15(17)22-21-14)12-4-7-18-16(20-12)19-11-5-8-23(3)9-6-11/h4,7,10-11H,5-6,8-9H2,1-3H3,(H,21,22)(H,18,19,20)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.72E+3	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for Biomedical Research Curated by ChEMBL					Assay Description Inhibition of human CDK1/cyclin B after 2 hrs by IMAP-FP assay				J Med Chem 53: 7938-57 (2010) Article DOI: 10.1021/jm100571n BindingDB Entry DOI: 10.7270/Q2T72HQV
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 6/G1/S-specific cyclin-D3 (Homo sapiens (Human))	BDBM50330265 (CHEMBL1271563 | [4-(5-Bromo-3-isopropyl-1H-pyrazol...) Show SMILES CC(C)c1[nH]nc(Br)c1-c1ccnc(NC2CCN(C)CC2)n1 Show InChI InChI=1S/C16H23BrN6/c1-10(2)14-13(15(17)22-21-14)12-4-7-18-16(20-12)19-11-5-8-23(3)9-6-11/h4,7,10-11H,5-6,8-9H2,1-3H3,(H,21,22)(H,18,19,20)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	231	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for Biomedical Research Curated by ChEMBL					Assay Description Inhibition of human CDK6/cyclin D3 after 2 hrs by TR-FRET assay				J Med Chem 53: 7938-57 (2010) Article DOI: 10.1021/jm100571n BindingDB Entry DOI: 10.7270/Q2T72HQV
					More data for this Ligand-Target Pair
Cyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM50330265 (CHEMBL1271563 | [4-(5-Bromo-3-isopropyl-1H-pyrazol...) Show SMILES CC(C)c1[nH]nc(Br)c1-c1ccnc(NC2CCN(C)CC2)n1 Show InChI InChI=1S/C16H23BrN6/c1-10(2)14-13(15(17)22-21-14)12-4-7-18-16(20-12)19-11-5-8-23(3)9-6-11/h4,7,10-11H,5-6,8-9H2,1-3H3,(H,21,22)(H,18,19,20)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.04E+3	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for Biomedical Research Curated by ChEMBL					Assay Description Inhibition of human CDK2/cyclin A after 2 hrs by IMAP-FP assay				J Med Chem 53: 7938-57 (2010) Article DOI: 10.1021/jm100571n BindingDB Entry DOI: 10.7270/Q2T72HQV
					More data for this Ligand-Target Pair