BDBM50330689 4-methyl-5-phenethyl-2-phenyl-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione::CHEMBL1277212

SMILES: Cc1n(CCc2ccccc2)c(=O)cc2[nH]n(-c3ccccc3)c(=O)c12

InChI Key: InChIKey=ICYYTFBMNVALJS-UHFFFAOYSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50330689   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
NADPH oxidase 4 (Homo sapiens (Human))	BDBM50330689 (4-methyl-5-phenethyl-2-phenyl-1H-pyrazolo[4,3-c]py...) Show SMILES Cc1n(CCc2ccccc2)c(=O)cc2[nH]n(-c3ccccc3)c(=O)c12 Show InChI InChI=1S/C21H19N3O2/c1-15-20-18(22-24(21(20)26)17-10-6-3-7-11-17)14-19(25)23(15)13-12-16-8-4-2-5-9-16/h2-11,14,22H,12-13H2,1H3	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	5.23E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genkyotex, S.A. Curated by ChEMBL					Assay Description Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPH				J Med Chem 53: 7715-30 (2010) Article DOI: 10.1021/jm100773e BindingDB Entry DOI: 10.7270/Q2KH0NKJ
					More data for this Ligand-Target Pair