BDBM50330725 2-(2-methoxyethyl)-4-methyl-5-(pyridin-2-ylmethyl)-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione::CHEMBL1277033

SMILES: COCCn1[nH]c2cc(=O)n(Cc3ccccn3)c(C)c2c1=O

InChI Key: InChIKey=FKAKWDOGKQHZKQ-UHFFFAOYSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50330725   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
NADPH oxidase 4 (Homo sapiens (Human))	BDBM50330725 (2-(2-methoxyethyl)-4-methyl-5-(pyridin-2-ylmethyl)...) Show SMILES COCCn1[nH]c2cc(=O)n(Cc3ccccn3)c(C)c2c1=O Show InChI InChI=1S/C16H18N4O3/c1-11-15-13(18-20(16(15)22)7-8-23-2)9-14(21)19(11)10-12-5-3-4-6-17-12/h3-6,9,18H,7-8,10H2,1-2H3	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	313	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genkyotex, S.A. Curated by ChEMBL					Assay Description Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPH				J Med Chem 53: 7715-30 (2010) Article DOI: 10.1021/jm100773e BindingDB Entry DOI: 10.7270/Q2KH0NKJ
					More data for this Ligand-Target Pair